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Study · Ex vivo tissue · guinea-pig · 1983

3 results

Immunohistochemical localization of substance P, vasoactive intestinal polypeptide and gastrin-releasing peptide in vas deferens and seminal vesicle, and the effect of these and eight other neuropeptides on resting tension and neurally evoked contractile activity.

Stjernquist M, Håkanson R, Leander S, Owman C, Sundler F, Uddman R

Regulatory peptides1 Sept 1983Cited by 55 (Europe PMC)

PMID6196810 (opens in a new tab)DOI10.1016/0167-0115(83)90282-3 (opens in a new tab)PepBankPUB-06196810
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In the isolated guinea-pig vas deferens, VIP had no effect on resting tension or on the response to electrical nerve stimulation.

    In plain wordsIn lab tests on guinea-pig tissue, VIP did not change muscle tension or the response to nerve stimulation in the vas deferens.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeGuinea-pig vas deferens resting tension and response to nerve stimulation
    Study

    guinea-pign: not reported in source

    isolated vas deferens or seminal vesicle
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP, Leu-enkephalin, cholecystokinin octapeptide (CCK-8), angiotensin II, vasopressin, neurotensin, bombesin, and GRP had no effect on either the resting tension or the response to electrical nerve stimulation.
    1 context sentence
    Summary · context
    The motor activity of the vas deferens and seminal vesicle of the guinea-pig was studied in vitro.
  2. 02LabEx vivo tissueActivity measurement

    In the isolated guinea-pig seminal vesicle, VIP had no effect on resting tension or on the response to transmural electrical stimulation.

    In plain wordsIn lab tests on guinea-pig tissue, VIP did not change muscle tension or the response to nerve stimulation in the seminal vesicle.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeGuinea-pig seminal vesicle resting tension and response to nerve stimulation
    Study

    guinea-pign: not reported in source

    isolated vas deferens or seminal vesicle
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP, Leu-enkephalin, CCK-8, angiotensin II, vasopressin, and neurotensin had no effect on the resting tension or on the response to transmural electrical stimulation.
    1 context sentence
    Summary · context
    The motor activity of the vas deferens and seminal vesicle of the guinea-pig was studied in vitro.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mouse, guinea-pig and rabbit, nerve fibres containing VIP supplied the smooth muscle layers and blood vessels of the vas deferens and seminal vesicle.

    In plain wordsIn mice, guinea pigs and rabbits, nerves with the body's own VIP supplied the muscle and blood vessels of these male organs.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-containing nerve fibres in vas deferens and seminal vesicle
    Study

    mouse, guinea-pig, rabbitn: not reported in source

    vas deferens and seminal vesicle sections
    Outcome group
    Endogenous peptide levels · Reproductive and sexual health

    Source sentences

    Summary
    Immunohistochemical studies of the vas deferens and seminal vesicle of mouse, guinea-pig, and rabbit showed the presence of nerve fibres containing vasoactive intestinal polypeptide (VIP), substance P (SP), and gastrin-releasing peptide (GRP) supplying the smooth muscle layers as well as blood vessels.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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