Preferential immunohistochemical localization of vasoactive intestinal polypeptide (VIP) in the sacral spinal cord of the cat: light and electron microscopic observations.

Honda CN, Réthelyi M, Petrusz P

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Nov 1983Cited by 80 (Europe PMC)

PMID6195317PMCIDPMC6564621DOI10.1523/jneurosci.03-11-02183.1983PepBankPUB-06195317

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the cat, VIP was located in small and medium-sized primary sensory neurons and in dorsal rootlets at sacral levels.
In plain wordsIn cats, the body's own VIP was found in sensory nerve cells and nerve roots of the lower spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP in sacral sensory neurons and dorsal rootlets
Study
catn: not reported in source
spinal cord and sensory ganglia sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
At sacral levels, VIP was found to be contained in small and medium-sized primary sensory neurons and in dorsal rootlets.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we have employed immunoperoxidase techniques to investigate the distribution of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the spinal cord and sensory ganglia of the cat.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0619531701
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the cat, ganglionectomy or dorsal rhizotomy caused a nearly complete loss of VIP immunoreactivity in the spinal cord.
In plain wordsIn cats, cutting the sensory nerve input removed almost all of the body's own VIP signal from the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP immunoreactivity after deafferentation
Study
catn: not reported in source
spinal cord and sensory ganglia sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Deafferentation, by either ganglionectomy or dorsal rhizotomy, resulted in a nearly complete loss of VIP immunoreactivity in the spinal cord.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we have employed immunoperoxidase techniques to investigate the distribution of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the spinal cord and sensory ganglia of the cat.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0619531702
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the cat, VIP fibres and terminals were most dense and extensive in sacral segments, unlike SP, SOM and CCK fibres.
In plain wordsIn cats, the body's own VIP fibres were most dense in the lower (sacral) spinal cord, unlike three other peptides.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableSpinal distribution of VIP fibres across segments
Study
catn: not reported in source
spinal cord and sensory ganglia sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
The spinal distribution of VIP fibers and terminals was most dense and extensive in sacral segments.
2 context sentences(design, population, supporting numbers)
Summary · context
In marked contrast, the distribution of VIP fibers, much like that of pelvic nerve afferents, was mostly confined to sacral segments.
Summary · context
In the present study we have employed immunoperoxidase techniques to investigate the distribution of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the spinal cord and sensory ganglia of the cat.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0619531703
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In the cat spinal cord, VIP-like immunoreactivity was found in dense core vesicles within axonal enlargements.
In plain wordsIn cats, the body's own VIP was found inside small storage sacs in nerve fibre swellings of the spinal cord.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableUltrastructural location of VIP immunoreactivity
Study
catn: not reported in source
spinal cord and sensory ganglia sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
At the ultrastructural level, VIP-like immunoreactivity was found in dense core vesicles within axonal enlargements containing both large dense core and smaller clear round vesicles.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we have employed immunoperoxidase techniques to investigate the distribution of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the spinal cord and sensory ganglia of the cat.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0619531704

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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