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Study · In vitro (cells) · mouse · 1983

6 results

The stimulatory effect of serum thymic factor (FTS) on spontaneous DNA synthesis of mouse thymocytes.

Blazsek I, Lenfant M

Cell and tissue kinetics1 May 1983Cited by 4 (Europe PMC)

PMID6188531 (opens in a new tab)PepBankPUB-06188531
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In mouse thymocytes, FTS stimulated DNA synthesis in a time- and concentration-dependent manner.

    In plain wordsIn cells from mice, FTS increased DNA synthesis with effects that depended on concentration and exposure time.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThymocyte DNA synthesis
    Study

    mousen: not reported in source

    young adult mouse thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1-100 pg/mlAs given in this study (mouse).

    Source sentences

    Summary
    In serum free RPMI 1640 medium, FTS stimulated [3H]thymidine incorporation into the DNA of young adult mouse thymocytes in a time and concentration dependent manner.
    2 context sentences
    Summary · context
    One to 100 pg/ml FTS were the effective concentrations, and the stimulation appeared 3 h after the treatment.
    Summary · context
    Synthetic serum thymic factor (FTS), a T-cell differentiating factor, was studied for its ability to modify the spontaneous DNA synthetic activity of immature or immunocompetent T cells in vitro.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured mouse bone marrow cells, FTS stimulated DNA synthesis less than in thymocytes.

    In plain wordsIn cells from mice, FTS increased DNA synthesis in bone marrow cells less than in thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseBone marrow cell DNA synthesis
    Study

    mousen: not reported in source

    cultured bone marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A comparable stimulation was noticed, but to a lesser extent, on cultured bone marrow cells.
    2 context sentences
    Summary · context
    In serum free RPMI 1640 medium, FTS stimulated [3H]thymidine incorporation into the DNA of young adult mouse thymocytes in a time and concentration dependent manner.
    Summary · context
    Synthetic serum thymic factor (FTS), a T-cell differentiating factor, was studied for its ability to modify the spontaneous DNA synthetic activity of immature or immunocompetent T cells in vitro.
  3. 03LabIn vitro (cells)Activity measurement

    In mouse spleen cells, FTS had no detectable effect on DNA synthesis across the times and concentrations studied.

    In plain wordsIn cells from mice, FTS did not detectably change spleen cell DNA synthesis.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeSpleen cell DNA synthesis
    Study

    mousen: not reported in source

    spleen cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, no effect could be detected on spleen cells whatever time or concentrations were studied.
    1 context sentence
    Summary · context
    Synthetic serum thymic factor (FTS), a T-cell differentiating factor, was studied for its ability to modify the spontaneous DNA synthetic activity of immature or immunocompetent T cells in vitro.
  4. 04LabIn vitro (cells)Activity measurement

    In hydroxyurea-treated mouse thymocytes, FTS did not stimulate DNA synthesis.

    In plain wordsIn cells from mice, FTS did not stimulate DNA synthesis in hydroxyurea-treated thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeDNA synthesis in hydroxyurea-treated thymocytes
    Study

    mousen: not reported in source

    hydroxyurea-treated thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither thymocytes treated in vitro with hydroxyurea nor the medullary, cortisol-resistant thymocytes were sensitive to FTS treatment.
    1 context sentence
    Summary · context
    Synthetic serum thymic factor (FTS), a T-cell differentiating factor, was studied for its ability to modify the spontaneous DNA synthetic activity of immature or immunocompetent T cells in vitro.
  5. 05LabIn vitro (cells)Activity measurement

    In medullary cortisol-resistant mouse thymocytes, FTS did not stimulate DNA synthesis.

    In plain wordsIn cells from mice, FTS did not stimulate DNA synthesis in medullary cortisol-resistant thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeDNA synthesis in medullary thymocytes
    Study

    mousen: not reported in source

    medullary cortisol-resistant thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither thymocytes treated in vitro with hydroxyurea nor the medullary, cortisol-resistant thymocytes were sensitive to FTS treatment.
    1 context sentence
    Summary · context
    Synthetic serum thymic factor (FTS), a T-cell differentiating factor, was studied for its ability to modify the spontaneous DNA synthetic activity of immature or immunocompetent T cells in vitro.
  6. 06LabIn vitro (cells)Activity measurement

    In PNA-positive mouse thymocytes, FTS significantly stimulated DNA synthesis.

    In plain wordsIn cells from mice, FTS significantly increased DNA synthesis in PNA-positive thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseDNA synthesis in PNA-positive thymocytes
    Study

    mousen: not reported in source

    PNA-positive thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, thymocytes bearing receptor to peanut agglutinin (PNA+) were significantly stimulated with FTS, which suggested that the target population of FTS belongs to the maturing, non-immunocompetent thymocyte compartment.
    1 context sentence
    Summary · context
    Synthetic serum thymic factor (FTS), a T-cell differentiating factor, was studied for its ability to modify the spontaneous DNA synthetic activity of immature or immunocompetent T cells in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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