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Study · In vitro (cells) · rat · 1983

3 results

Thymosin peptides and lymphokines do not directly stimulate adrenal corticosteroid production in vitro.

Vahouny GV, Kyeyune-Nyombi E, McGillis JP, Tare NS, Huang KY, Tombes R, Goldstein AL, Hall NR

Journal of immunology (Baltimore, Md. : 1950)1 Feb 1983Cited by 14 (Europe PMC)

PMID6184406 (opens in a new tab)DOI10.4049/jimmunol.130.2.791 (opens in a new tab)PepBankPUB-06184406
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    Thymosin alpha‑1 had no direct steroidogenic effect on rat adrenal fasciculata cells in vitro.

    In plain wordsIn rat adrenal cells in lab tests, thymosin alpha‑1 did not directly raise steroid output.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeDirect steroidogenic effect on adrenal cells
    Study

    ratn: not reported in source

    Rat adrenal fasciculata cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With this system, there was no direct steroidogenic effect of either the partially purified thymosin fraction 5, or any of the purified peptide components tested (thymosin alpha 1, alpha 7, or beta 4).
    1 context sentence
    Summary · context
    In the present study, the direct effect of certain components of the immune system on steroid output by rat adrenal fasciculata cells was tested.
  2. 02LabIn vitro (cells)Mechanism

    Thymosin alpha‑1 did not synergize the cellular response of adrenal cells to ACTH.

    In plain wordsIn rat adrenal cells in lab tests, thymosin alpha‑1 did not boost the response to ACTH.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSynergy with ACTH on adrenal cells
    Study

    ratn: not reported in source

    Rat adrenal fasciculata cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These peptides also did not synergize the cellular response to ACTH, nor did they induce cAMP production by a ACTH- and NaF-responsive adrenal membrane preparation.
    1 context sentence
    Summary · context
    In the present study, the direct effect of certain components of the immune system on steroid output by rat adrenal fasciculata cells was tested.
  3. 03LabIn vitro (cell-free)Mechanism

    Thymosin alpha‑1 did not induce cAMP production by an ACTH- and NaF-responsive adrenal membrane preparation.

    In plain wordsIn lab tests on rat adrenal membranes, thymosin alpha‑1 did not induce cAMP production.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changecAMP production in adrenal membranes
    Study

    ratn: not reported in source

    ACTH- and NaF-responsive adrenal membrane preparation
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These peptides also did not synergize the cellular response to ACTH, nor did they induce cAMP production by a ACTH- and NaF-responsive adrenal membrane preparation.
    1 context sentence
    Summary · context
    In the present study, the direct effect of certain components of the immune system on steroid output by rat adrenal fasciculata cells was tested.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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