In rats trained to discriminate ethanol from saline, the ethanol cue did not generalize to delta sleep-inducing peptide.
In plain wordsIn rats trained to recognise ethanol, delta sleep-inducing peptide did not produce ethanol-like responding.
- Outcome
- No significant changeEthanol-appropriate responding after DSIP
- Study
ratn: not reported in source
Ethanol drug-discrimination task in Sprague-Dawley rats- Outcome group
- Addiction, withdrawal and alcohol intake · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
In addition, (DA1a2-Met5)-enkephalin-ol, (DAla2-Met(O)5)-enkephalin-ol, substance P, delta sleep-inducing peptide, and bombesin were tested for their ability to elicit ethanol appropriate responding. The EtOH cue generalized to none of these peptides.
1 context sentence(design, population, supporting numbers)
Male Sprague-Dawley rats were trained to discriminate ethanol (2 g/kg, PO: EtOH) from saline (10 ml/kg, PO: SAL) in a two-bar positively reinforced operant task on a VI 15 sec schedule.