Magnocellular hypothalamic projections to the lower brain stem and spinal cord of the rat. Immunocytochemical evidence for predominance of the oxytocin-neurophysin system compared to the vasopressin-neurophysin system.

Nilaver G, Zimmerman EA, Wilkins J, Michaels J, Hoffman D, Silverman AJ

Neuroendocrinology1 Jan 1980Cited by 210 (Europe PMC)

PMID6154267DOI10.1159/000122991PepBankPUB-06154267

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In laboratory sections from normal and homozygous Brattleboro rats, caudal paraventricular projections were predominantly oxytocinergic based on neurophysin-marker staining.
In plain wordsIn lab tests of rat tissue, marker staining indicated that caudal paraventricular projections were mainly oxytocinergic.
Peptide
Oxytocin
Outcome
Not applicableOxytocinergic caudal paraventricular projections
Study
ratn: not reported in source
hypothalamic projections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Our results indicate that the axons which constitute the caudal projections from the paraventricular nucleus are predominately oxytocinergic, the vasopressinergic innervation being limited to the nucleus tractus solitarius, the dorsal motor nucleus of vagus, and the substantia gelatinosa.
2 context sentences(design, population, supporting numbers)
Summary · context
The proportion of oxytocin-neurophysin (OTNP) axons to vasopressin-neurophysin (VPNP) axons in these structures is unknown.
Summary · context
In this study two approaches have been used: (1) comparison of immunostaining for neurophysin in normal versus homozygous Brattleboro rats with diabetes insipidus (HODI) which lack VPNP, and (2) application of an antiserum to both rat neurophysins absorbed with HODI rat hypothalamic-pituitary extrac…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0615426701
02LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In laboratory sections from normal and homozygous Brattleboro rats, similar numbers of neurophysin-marker-reactive fibers were seen in the medulla and spinal cord.
In plain wordsIn lab tests of normal and Brattleboro rat tissue, similar neurophysin-marker fibers were seen in medulla and spinal cord.
Peptide
Oxytocin
Outcome
Not applicableReactive-fiber abundance in normal and Brattleboro rats
Study
ratn: not reported in source
medulla and spinal cord
Comparator
normal versus homozygous Brattleboro rats with diabetes insipidus (HODI)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
A similar number of reactive fibers were seen in the medulla and spinal cord of normal and HODI rats.
2 context sentences(design, population, supporting numbers)
Summary · context
The proportion of oxytocin-neurophysin (OTNP) axons to vasopressin-neurophysin (VPNP) axons in these structures is unknown.
Summary · context
In this study two approaches have been used: (1) comparison of immunostaining for neurophysin in normal versus homozygous Brattleboro rats with diabetes insipidus (HODI) which lack VPNP, and (2) application of an antiserum to both rat neurophysins absorbed with HODI rat hypothalamic-pituitary extrac…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0615426702
03LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In laboratory sections from rats, no neurophysin-marker-positive perikarya were observed caudal to the hypothalamus.
In plain wordsIn lab tests of rat tissue, no cell bodies positive for a neurophysin marker were seen below the hypothalamus.
Peptide
Oxytocin
Outcome
Not applicablePositive perikarya caudal to the hypothalamus
Study
ratn: not reported in source
brainstem and spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
No positive perikarya were observed caudal to the hypothalamus.
2 context sentences(design, population, supporting numbers)
Summary · context
The proportion of oxytocin-neurophysin (OTNP) axons to vasopressin-neurophysin (VPNP) axons in these structures is unknown.
Summary · context
In this study two approaches have been used: (1) comparison of immunostaining for neurophysin in normal versus homozygous Brattleboro rats with diabetes insipidus (HODI) which lack VPNP, and (2) application of an antiserum to both rat neurophysins absorbed with HODI rat hypothalamic-pituitary extrac…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0615426703
04LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In laboratory sections from rats, neurophysin-marker-reactive fibers in the medulla appeared to terminate in the nucleus of the solitary tract and dorsal motor nucleus of the vagus nerve.
In plain wordsIn lab tests of rat tissue, fibers marked with a neurophysin marker appeared to end in two lower-brainstem nuclei.
Peptide
Oxytocin
Outcome
Not applicableMedullary fiber termination
Study
ratn: not reported in source
medulla
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Fibers in the medulla appeared to terminate in the nucleus of the solitary tract and in the dorsal motor nucleus of the vagus nerve.
2 context sentences(design, population, supporting numbers)
Summary · context
The proportion of oxytocin-neurophysin (OTNP) axons to vasopressin-neurophysin (VPNP) axons in these structures is unknown.
Summary · context
In this study two approaches have been used: (1) comparison of immunostaining for neurophysin in normal versus homozygous Brattleboro rats with diabetes insipidus (HODI) which lack VPNP, and (2) application of an antiserum to both rat neurophysins absorbed with HODI rat hypothalamic-pituitary extrac…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0615426704
05LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In laboratory sections from rats, neurophysin-marker-positive fibers throughout the cord were present in the substantia gelatinosa and intermediolateral grey.
In plain wordsIn lab tests of rat tissue, fibers marked with a neurophysin marker were present in two spinal-cord regions.
Peptide
Oxytocin
Outcome
Not applicablePositive fibers in the spinal cord
Study
ratn: not reported in source
spinal cord
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Positive fibers throughout the cord were present in the substantia gelatinosa and in the intermediolateral grey.
2 context sentences(design, population, supporting numbers)
Summary · context
The proportion of oxytocin-neurophysin (OTNP) axons to vasopressin-neurophysin (VPNP) axons in these structures is unknown.
Summary · context
In this study two approaches have been used: (1) comparison of immunostaining for neurophysin in normal versus homozygous Brattleboro rats with diabetes insipidus (HODI) which lack VPNP, and (2) application of an antiserum to both rat neurophysins absorbed with HODI rat hypothalamic-pituitary extrac…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0615426705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 02:54 UTC
First added · source update from Europe PMC

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