Central action of melanostatin (MIF-1) in mice.

Brus R, Szkilnik R, Stanosek B, Makowska B, Piguła J

Acta physiologica Polonica1 Sept 1984Cited by 1 (Europe PMC)

PMID6152791PepBankPUB-06152791

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, MIF‑1 depressed behavior.
In plain wordsIn mice, MIF‑1 reduced behavioral activity.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseBehavioral depression
Study
mousen: not reported in source
Mouse behavioral and pain tests
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
Dose not stated · lateral cerebral ventricleAs given in this study (mouse).
Source sentences
Summary
It was demonstrated that MIF-1 exerted a depressing effect on the behaviour of mice, increased the intensity of apomorphine-induced stereotypy and weakened chlorpromazine-induced catalepsy.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test.
Report a problemFND-0615279101
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, MIF‑1 increased the intensity of apomorphine-induced stereotypy.
In plain wordsIn mice, MIF‑1 increased repetitive behavior induced by apomorphine.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseApomorphine-induced stereotypy
Study
mousen: not reported in source
Mouse behavioral and pain tests
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · lateral cerebral ventricleAs given in this study (mouse).
Source sentences
Summary
It was demonstrated that MIF-1 exerted a depressing effect on the behaviour of mice, increased the intensity of apomorphine-induced stereotypy and weakened chlorpromazine-induced catalepsy.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test.
Report a problemFND-0615279102
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, MIF‑1 weakened chlorpromazine-induced catalepsy.
In plain wordsIn mice, MIF‑1 reduced immobility induced by chlorpromazine.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseChlorpromazine-induced catalepsy
Study
mousen: not reported in source
Mouse behavioral and pain tests
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · lateral cerebral ventricleAs given in this study (mouse).
Source sentences
Summary
It was demonstrated that MIF-1 exerted a depressing effect on the behaviour of mice, increased the intensity of apomorphine-induced stereotypy and weakened chlorpromazine-induced catalepsy.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test.
Report a problemFND-0615279103
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, MIF‑1 produced analgesia.
In plain wordsIn mice, MIF‑1 reduced pain responses.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseAnalgesia
Study
mousen: not reported in source
Mouse behavioral and pain tests
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · lateral cerebral ventricleAs given in this study (mouse).
Source sentences
Summary
Moreover, an analgesic action of MIF-1 was demonstrated which was blocked with naloxone.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test.
Report a problemFND-0615279104

Studies that did not test the peptide alone1

In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

05AnimalNot a test of MIF-1 (Pro-Leu-Gly-NH2) aloneAnimal study (in vivo)Mechanism
In mice, naloxone blocked the analgesic action of MIF‑1.
In plain wordsIn mice, naloxone blocked pain relief from MIF‑1 compared with MIF‑1 alone.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseNaloxone blockade of MIF-1 analgesia
Study
mousen: not reported in source
Mouse behavioral and pain tests
Comparator
MIF-1 without naloxone
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, an analgesic action of MIF-1 was demonstrated which was blocked with naloxone.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test.
In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).
Report a problemFND-0615279105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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