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Study · Animal study (in vivo) · rat · 1984

2 results

Neuropeptides and social behavior of rats tested in dyadic encounters.

Niesink RJ, van Ree JM

Neuropeptides1 Nov 1984Cited by 22 (Europe PMC)

PMID6151143 (opens in a new tab)DOI10.1016/0143-4179(84)90092-1 (opens in a new tab)PepBankPUB-06151143
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In isolated rats, PLG reversed the isolation-induced increase in social activity.

    In plain wordsIn rats, PLG reversed the increase in social activity after isolation.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseIsolation-induced social activity
    Study

    ratn: not reported in source

    Social interaction test with isolated and non-isolated partners
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    Systemic injection of certain neuropeptides, i.c. prolyl-leucyl-glycinamide (PLG), thyrotropin releasing hormone (TRH) and the ACTH 4-9 analog ORG 2766, reversed the isolation-induced increase in social activity, similarly as previously observed with antidepressant drugs.
    1 context sentence
    Summary · context
    The effects of various neuropeptides on social behavior was studied in a test procedure in which 7-day isolated animals were tested together with non-isolated partners in dyadic encounters.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG did not affect non-social explorative behavior during the social interaction test.

    In plain wordsIn rats, PLG did not change non-social exploration during the social interaction test.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeNon-social explorative behavior
    Study

    ratn: not reported in source

    Social interaction test with isolated and non-isolated partners
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · systemic injectionAs given in this study (rat).

    Source sentences

    Summary
    The action of the peptides may be rather specific for social behavior, since none of the neuropeptides affected non-social explorative behaviors of the rats during the social interaction test.
    2 context sentences
    Summary · context
    Systemic injection of certain neuropeptides, i.c. prolyl-leucyl-glycinamide (PLG), thyrotropin releasing hormone (TRH) and the ACTH 4-9 analog ORG 2766, reversed the isolation-induced increase in social activity, similarly as previously observed with antidepressant drugs.
    Summary · context
    The effects of various neuropeptides on social behavior was studied in a test procedure in which 7-day isolated animals were tested together with non-isolated partners in dyadic encounters.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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