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Study · Animal study (in vivo) · mouse · 1984

4 results

Comparative effects of prolyl-leucyl-glycinamide and naloxone on morphine-induced inhibition of gastrointestinal transit.

Pillai NP, Bhargava HN

Pharmacology, biochemistry, and behavior1 Sept 1984Cited by 1 (Europe PMC)

PMID6149566 (opens in a new tab)DOI10.1016/s0091-3057(84)80096-9 (opens in a new tab)PepBankPUB-06149566
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intraperitoneal MIF did not affect gastrointestinal transit.

    In plain wordsIn mice, intraperitoneal MIF did not change movement through the gut.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeGastrointestinal transit after intraperitoneal MIF
    Study

    mousen: not reported in source

    Charcoal meal gastrointestinal transit test
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    1-10 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    MIF administered intraperitoneally (IP) (1-10 mg/kg) or intracerebroventricularly (ICV) (10 micrograms/mouse) had no effect on the transit.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF) and naloxone on the gastrointestinal transit in mice were investigated using the charcoal meal test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ventricular MIF did not affect gastrointestinal transit.

    In plain wordsIn mice, MIF injected into a brain ventricle did not change movement through the gut.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeGastrointestinal transit after ventricular MIF
    Study

    mousen: not reported in source

    Charcoal meal gastrointestinal transit test
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 micrograms/mouse · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    MIF administered intraperitoneally (IP) (1-10 mg/kg) or intracerebroventricularly (ICV) (10 micrograms/mouse) had no effect on the transit.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF) and naloxone on the gastrointestinal transit in mice were investigated using the charcoal meal test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intraperitoneal MIF did not affect morphine-induced inhibition of gastrointestinal transit.

    In plain wordsIn mice, intraperitoneal MIF did not change the slowing of gut movement caused by morphine.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMorphine-inhibited transit after intraperitoneal MIF
    Study

    mousen: not reported in source

    Charcoal meal gastrointestinal transit test
    Comparator
    Morphine
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    1-10 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The morphine-induced inhibition of the transit was not affected by MIF whether given by IP or ICV route.
    2 context sentences
    Summary · context
    MIF administered intraperitoneally (IP) (1-10 mg/kg) or intracerebroventricularly (ICV) (10 micrograms/mouse) had no effect on the transit.
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF) and naloxone on the gastrointestinal transit in mice were investigated using the charcoal meal test.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ventricular MIF did not affect morphine-induced inhibition of gastrointestinal transit.

    In plain wordsIn mice, ventricular MIF did not change the slowing of gut movement caused by morphine.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMorphine-inhibited transit after ventricular MIF
    Study

    mousen: not reported in source

    Charcoal meal gastrointestinal transit test
    Comparator
    Morphine
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 micrograms/mouse · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    The morphine-induced inhibition of the transit was not affected by MIF whether given by IP or ICV route.
    2 context sentences
    Summary · context
    MIF administered intraperitoneally (IP) (1-10 mg/kg) or intracerebroventricularly (ICV) (10 micrograms/mouse) had no effect on the transit.
    Summary · context
    The effects of prolyl-leucyl-glycinamide (MIF) and naloxone on the gastrointestinal transit in mice were investigated using the charcoal meal test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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