The effects of growth hormone (GH)-releasing peptides on GH secretion in perifused pituitary cells of adult male rats.

Badger TM, Millard WJ, McCormick GF, Bowers CY, Martin JB

Endocrinology1 Oct 1984Cited by 51 (Europe PMC)

PMID6148232DOI10.1210/endo-115-4-1432PepBankPUB-06148232

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In rat pituitary cells, GHRP was less potent than GRF-44 for GH secretion.
In plain wordsIn cells from rats, GHRP was less potent than GRF-44 for growth hormone release.
Peptide
GHRP-6
Outcome
DecreaseGH release potency
Study
ratn: not reported in source
perifused dispersed anterior pituitary cells from adult male rats
Comparator
GRF-44
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Relative GRF-44 potency
60 times
versus GHRP
Source sentences
Summary
GRF-44 was 60 times more potent than GHRP and elicited linear increases in GH secretion between 0.3 and 30 ng (0.06-6 pmol), whereas the GHRP dose range was 3-300 ng (3.44-344 pmol).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the GH secretory activities of two distinctively different peptides: human pancreatic GH-releasing factor 44 (GRF-44) and a synthetic peptide His-DTrp-Ala-Trp-DPhe-Lys-NH2 (GHRP).
Summary · context
GH secretion was studied in perifused dispersed anterior pituitary cells from male rats 24 or 48 h postdispersion.
Report a problemFND-0614823201
02LabIn vitro (cells)Efficacy outcome
In rat pituitary cells, GHRP stimulated GH secretion over the reported dose range.
In plain wordsIn cells from rats, GHRP stimulated growth hormone release across the tested dose range.
Peptide
GHRP-6
Outcome
IncreaseDose-dependent GH secretion
Study
ratn: not reported in source
perifused dispersed anterior pituitary cells from adult male rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
3-300 ng (3.44-344 pmol)As given in this study (rat).
Source sentences
Summary
GRF-44 was 60 times more potent than GHRP and elicited linear increases in GH secretion between 0.3 and 30 ng (0.06-6 pmol), whereas the GHRP dose range was 3-300 ng (3.44-344 pmol).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the GH secretory activities of two distinctively different peptides: human pancreatic GH-releasing factor 44 (GRF-44) and a synthetic peptide His-DTrp-Ala-Trp-DPhe-Lys-NH2 (GHRP).
Summary · context
GH secretion was studied in perifused dispersed anterior pituitary cells from male rats 24 or 48 h postdispersion.
Report a problemFND-0614823202
03LabIn vitro (cells)Efficacy outcome
In rat pituitary cells, hourly GHRP pulses stimulated consistent GH responses.
In plain wordsIn cells from rats, hourly GHRP doses repeatedly stimulated growth hormone release.
Peptide
GHRP-6
Outcome
IncreaseGH response to hourly pulses
Study
ratn: not reported in source
perifused dispersed anterior pituitary cells from adult male rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
30 ngAs given in this study (rat).
Source sentences
Summary
Hourly pulses of GHRP (30 ng) and GRF-44 (12.5 ng) stimulated consistent GH responses.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the GH secretory activities of two distinctively different peptides: human pancreatic GH-releasing factor 44 (GRF-44) and a synthetic peptide His-DTrp-Ala-Trp-DPhe-Lys-NH2 (GHRP).
Summary · context
GH secretion was studied in perifused dispersed anterior pituitary cells from male rats 24 or 48 h postdispersion.
Report a problemFND-0614823203
04LabIn vitro (cells)Efficacy outcome
In rat pituitary cells, continuous GHRP infusion caused desensitization.
In plain wordsIn cells from rats, continuous GHRP exposure reduced responsiveness.
Peptide
GHRP-6
Outcome
DecreaseDesensitization during continuous infusion
Study
ratn: not reported in source
perifused dispersed anterior pituitary cells from adult male rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · continuous infusionAs given in this study (rat).
Source sentences
Summary
Continuous infusion of either peptide resulted in desensitization, with GH secretion being monophasic during GHRP infusion and biphasic during GRF-44 infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the GH secretory activities of two distinctively different peptides: human pancreatic GH-releasing factor 44 (GRF-44) and a synthetic peptide His-DTrp-Ala-Trp-DPhe-Lys-NH2 (GHRP).
Summary · context
GH secretion was studied in perifused dispersed anterior pituitary cells from male rats 24 or 48 h postdispersion.
Report a problemFND-0614823204
05LabIn vitro (cells)Efficacy outcome
In rat pituitary cells, GH secretion was monophasic during GHRP infusion and biphasic during GRF-44 infusion.
In plain wordsIn cells from rats, GHRP produced one phase of hormone release, whereas GRF-44 produced two phases.
Peptide
GHRP-6
Outcome
Not applicableGH secretion pattern during continuous infusion
Study
ratn: not reported in source
perifused dispersed anterior pituitary cells from adult male rats
Comparator
GRF-44
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · continuous infusionAs given in this study (rat).
Source sentences
Summary
Continuous infusion of either peptide resulted in desensitization, with GH secretion being monophasic during GHRP infusion and biphasic during GRF-44 infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the GH secretory activities of two distinctively different peptides: human pancreatic GH-releasing factor 44 (GRF-44) and a synthetic peptide His-DTrp-Ala-Trp-DPhe-Lys-NH2 (GHRP).
Summary · context
GH secretion was studied in perifused dispersed anterior pituitary cells from male rats 24 or 48 h postdispersion.
Report a problemFND-0614823205

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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