The activity of synthetic analogs of serum thymic factor (FTS) to convert mouse pre-T cells into Thy-1 positive cells.

Yoshida T, Takaoki M, Kato K, Takeuchi M, Nishimura O, Fujino M, Kakinuma A

International journal of immunopharmacology1 Jan 1984Cited by 3 (Europe PMC)

PMID6145673DOI10.1016/0192-0561(84)90009-2PepBankPUB-06145673

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In mouse pre-T cells, FTS converted Thy-1-negative cells into Thy-1-positive cells.
In plain wordsIn cells from mice, FTS induced the Thy-1 marker.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseThy-1 antigen induction
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Thy-1 negative cells were converted into Thy-1 positive cells by FTS and some of its analogs.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
Report a problemFND-0614567301

Studies that did not test the peptide alone7

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

02LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, deleting amino-terminal pGlu from FTS did not alter Thy-1 induction activity.
In plain wordsIn cells from mice, FTS without amino-terminal pGlu retained the activity of intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeActivity after amino-terminal pGlu deletion
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Deletion of pGlu at the amino terminus of FTS did not alter the activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567302
03LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, des(pGlu, Ala)-FTS was inactive for Thy-1 induction.
In plain wordsIn cells from mice, FTS without amino-terminal pGlu and Ala was inactive, unlike intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseActivity after pGlu and Ala deletion
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Des ( pGlu1 , Ala2)-FTS and des ( pGlu1 , Ala2, Lys3 )-FTS were inactive and deletion of the carboxyl terminal residue, Asn, also resulted in the loss of activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567303
04LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, des(pGlu, Ala, Lys)-FTS was inactive for Thy-1 induction.
In plain wordsIn cells from mice, FTS without amino-terminal pGlu, Ala and Lys was inactive, unlike intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseActivity after pGlu, Ala and Lys deletion
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Des ( pGlu1 , Ala2)-FTS and des ( pGlu1 , Ala2, Lys3 )-FTS were inactive and deletion of the carboxyl terminal residue, Asn, also resulted in the loss of activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567304
05LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, deleting carboxyl-terminal Asn from FTS eliminated activity.
In plain wordsIn cells from mice, FTS without carboxyl-terminal Asn lost activity compared with intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseActivity after carboxyl-terminal Asn deletion
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Des ( pGlu1 , Ala2)-FTS and des ( pGlu1 , Ala2, Lys3 )-FTS were inactive and deletion of the carboxyl terminal residue, Asn, also resulted in the loss of activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567305
06LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, substitution or modification of terminal pGlu or Asn markedly reduced FTS activity.
In plain wordsIn cells from mice, changes to terminal FTS residues markedly reduced activity compared with intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseActivity after terminal residue modification
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Substitution or modification of pGlu1 and Asn9 with an amino acid, an acyl group or an amine caused a marked reduction of the activity.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567306
07LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, replacing FTS Lys with Arg preserved activity.
In plain wordsIn cells from mice, FTS with Arg instead of Lys retained the activity of intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeActivity after Lys replacement with Arg
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The residue 3, Lys, could be substituted without any loss of the activity by Arg, but not by Leu.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567307
08LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Activity measurement
In mouse pre-T cells, replacing FTS Lys with Leu did not preserve activity.
In plain wordsIn cells from mice, FTS with Leu instead of Lys had less activity than intact FTS.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseActivity after Lys replacement with Leu
Study
mousen: not reported in source
pre-T cells from athymic nu/nu mouse spleens
Comparator
Intact FTS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
The residue 3, Lys, could be substituted without any loss of the activity by Arg, but not by Leu.
2 context sentences(design, population, supporting numbers)
Summary · context
Serum thymic factor (FTS) and its 33 analogs were compared with regard to the ability to induce Thy-1 antigen on mouse pre-T cells.
Summary · context
The pre-T cells were prepared from spleen cells of athymic nu/nu mice by passing them through a nylon wool column, and the induction of Thy-1 antigen was analysed using a fluorescence-activated cell sorter.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-0614567308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.