In haloperidol-treated rats, Pro-Leu-Gly-NH2 pretreatment inhibited the enhanced locomotor response to apomorphine.
In plain wordsIn rats given haloperidol, PLG reduced the enhanced movement response to apomorphine compared with haloperidol alone.
- Peptide
- MIF-1 (Pro-Leu-Gly-NH2)
- Outcome
- DecreaseApomorphine-induced locomotor response after haloperidol
- Study
ratn: not reported in source
Male Sprague-Dawley rats- Comparator
- Haloperidol without peptide pretreatment
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- 2 mg/kg per day · subcutaneousAs given in this study (rat).
Source sentences
Subcutaneous administration of Pro-Leu-Gly-NH2 or cyclo(Leu-Gly) in doses of 2 mg/kg per day, given prior to the injection of haloperidol, inhibited both the enhanced response to apomorphine as well as the increase in the number of binding sites for [3H]spiroperidol in the striatum.
2 context sentences(design, population, supporting numbers)
Oral administration of haloperidol (1.5 mg/kg per day) for 21 days induced supersensitivity of dopamine receptors as shown by enhanced locomotor activity in response to apomorphine, and an increase in the number of binding sites for [3H]spiroperidol in the striatum.
The effects of melanotropin release-inhibiting factor, a tripeptide (Pro-Leu-Gly-NH2) derived from the hypothalamus, and its enzymatically stable analog, cyclo(Leu-Gly) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to male Sprague-Dawley rats was determined.