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Study · Animal study (in vivo) · rat · 1984

4 results

Arginine-vasopressin inhibits centrally induced pressor responses by involving hippocampal mechanisms.

Versteeg CA, De Jong W, Bohus B

Brain research1 Feb 1984Cited by 20 (Europe PMC)

PMID6140991 (opens in a new tab)DOI10.1016/0006-8993(84)90767-4 (opens in a new tab)PepBankPUB-06140991
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, ventricular PLG reduced the systolic pressor response to mesencephalic reticular formation stimulation.

    In plain wordsIn rats, PLG reduced the blood pressure rise after brain stimulation.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseStimulation-induced systolic pressor response
    Study

    ratn: not reported in source

    Urethane-anesthetized rats with mesencephalic reticular formation stimulation
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Administration of arginine-vasopressin (AVP) or prolyl-leucyl-glycinamide (PLG) into a lateral cerebral ventricle reduced the magnitude of systolic blood pressure increase (pressor response) induced by electrical stimulation of the mesencephalic reticular formation (MRF) in urethane-anesthetized rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG administration did not change basal mean arterial pressure.

    In plain wordsIn rats, PLG did not change resting blood pressure.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeBasal mean arterial pressure
    Study

    ratn: not reported in source

    Urethane-anesthetized rats with mesencephalic reticular formation stimulation
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Neither hippocampal damage nor peptide administrations resulted in changes in mean arterial blood pressure (basal BP).
    1 context sentence
    Summary · context
    Administration of arginine-vasopressin (AVP) or prolyl-leucyl-glycinamide (PLG) into a lateral cerebral ventricle reduced the magnitude of systolic blood pressure increase (pressor response) induced by electrical stimulation of the mesencephalic reticular formation (MRF) in urethane-anesthetized rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, ventricular PLG did not affect the cardiac response to mesencephalic reticular formation stimulation.

    In plain wordsIn rats, PLG did not change the heart response to brain stimulation.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeStimulation-induced cardiac response
    Study

    ratn: not reported in source

    Urethane-anesthetized rats with mesencephalic reticular formation stimulation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Hippocampal damage or intracerebroventricular administration of AVP and PLG failed to affect the cardiac response.
    1 context sentence
    Summary · context
    Bradycardiac response accompanied the BP increase during MRF stimulation.

Studies that did not test the peptide alone1

In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

  1. 04AnimalNot a test of MIF-1 (Pro-Leu-Gly-NH2) aloneAnimal study (in vivo)Mechanism

    In rats, hippocampal lesions only slightly reduced PLG inhibition of the stimulation-induced pressor response.

    In plain wordsIn rats, hippocampal damage only slightly reduced PLG's effect on the blood pressure response.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreasePLG pressor inhibition after hippocampal lesion
    Study

    ratn: not reported in source

    Urethane-anesthetized rats with mesencephalic reticular formation stimulation
    Comparator
    PLG without hippocampal lesion
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    However, the effect of PLG was only slightly reduced by hippocampal lesion.
    1 context sentence
    Summary · context
    Administration of arginine-vasopressin (AVP) or prolyl-leucyl-glycinamide (PLG) into a lateral cerebral ventricle reduced the magnitude of systolic blood pressure increase (pressor response) induced by electrical stimulation of the mesencephalic reticular formation (MRF) in urethane-anesthetized rats.

    In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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