Reduction of a centrally induced pressor response by neurohypophyseal peptides: the involvement of lower brainstem mechanisms.

Versteeg CA, Cransberg K, De Jong W, Bohus B

European journal of pharmacology1 Oct 1983Cited by 15 (Europe PMC)

PMID6140170DOI10.1016/0014-2999(83)90450-8PepBankPUB-06140170

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, oxytocin attenuated the electrically induced pressor response.
In plain wordsIn rats under anesthesia, oxytocin reduced the blood pressure response to electrical stimulation.
Peptide
Oxytocin
Outcome
DecreasePressor response
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · fourth cerebral ventricleAs given in this study (rat).
Source sentences
Summary
Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magnitude of the pressor response.
1 context sentence(design, population, supporting numbers)
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017001
02AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, PLG attenuated the electrically induced pressor response.
In plain wordsIn rats under anesthesia, PLG reduced the blood pressure response to electrical stimulation.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreasePressor response
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · fourth cerebral ventricleAs given in this study (rat).
Source sentences
Summary
Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magnitude of the pressor response.
1 context sentence(design, population, supporting numbers)
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017002
03AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, PLG was somewhat more potent than oxytocin against the pressor response.
In plain wordsIn rats under anesthesia, PLG reduced the blood pressure response somewhat more potently than oxytocin.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreasePressor response potency
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Comparator
Oxytocin
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · fourth cerebral ventricleAs given in this study (rat).
Source sentences
Summary
OXT-(7-9) was somewhat more potent than OXT and its effect was dose-dependent.
1 context sentence(design, population, supporting numbers)
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017003
04AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, the effect of PLG on the pressor response was dose-dependent.
In plain wordsIn rats under anesthesia, the PLG effect on the blood pressure response depended on dose.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
Not applicableDose dependence of pressor response attenuation
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · fourth cerebral ventricleAs given in this study (rat).
Source sentences
Summary
OXT-(7-9) was somewhat more potent than OXT and its effect was dose-dependent.
1 context sentence(design, population, supporting numbers)
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017004
05AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, PLG microinjection into the dorsal raphe nucleus reduced the pressor response.
In plain wordsIn rats under anesthesia, PLG injection into the dorsal raphe nucleus reduced the blood pressure response.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreasePressor response after dorsal raphe injection
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · microinjection into dorsal raphe nucleusAs given in this study (rat).
Source sentences
Summary
Microinjection of OXT-(7-9) into the dorsal raphe nucleus reduced the pressor response as well.
1 context sentence(design, population, supporting numbers)
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017005
06AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, oxytocin did not affect the magnitude of the bradycardiac response.
In plain wordsIn rats under anesthesia, oxytocin did not change the slowing of heart rate.
Peptide
Oxytocin
Outcome
No significant changeBradycardiac response
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · fourth cerebral ventricleAs given in this study (rat).
Source sentences
Summary
None of these peptides affected the magnitude of the bradycardiac response.
2 context sentences(design, population, supporting numbers)
Summary · context
Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magnitude of the pressor response.
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017006
07AnimalAnimal study (in vivo)Efficacy outcome
In anesthetized rats, PLG did not affect the magnitude of the bradycardiac response.
In plain wordsIn rats under anesthesia, PLG did not change the slowing of heart rate.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeBradycardiac response
Study
ratn: not reported in source
Urethane-anesthetized rats with electrically induced neurogenic hypertension
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
None of these peptides affected the magnitude of the bradycardiac response.
2 context sentences(design, population, supporting numbers)
Summary · context
Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magnitude of the pressor response.
Summary · context
Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension.
Report a problemFND-0614017007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 2
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:54 UTC
First added · source update from Europe PMC

Subjects

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Publication types

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MeSH terms

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