Effects of oxytocin, des-glycinamide-oxytocin and anti-oxytocin serum on the alpha-MPT-induced disappearance of catecholamines in the rat brain.

Kovács G, Telegdy G

Brain research1 Jun 1983Cited by 17 (Europe PMC)

PMID6135495DOI10.1016/0006-8993(83)90497-3PepBankPUB-06135495

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, peripheral oxytocin facilitated alpha-MPT-induced noradrenaline disappearance in the mesencephalon.
In plain wordsIn rats, peripheral oxytocin increased alpha-MPT-induced noradrenaline disappearance in the midbrain.
Peptide
Oxytocin
Outcome
IncreaseMesencephalic noradrenaline disappearance after alpha-MPT
Study
ratn: not reported in source
brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · peripheral injectionAs given in this study (rat).
Source sentences
Summary
Peripheral injection of OXT facilitated the alpha-MPT-induced disappearance of noradrenaline (NA) in the mesencephalon.
Report a problemFND-0613549501
02AnimalAnimal study (in vivo)Mechanism
In rats, peripheral oxytocin inhibited dopamine disappearance in the mesencephalon after alpha-MPT.
In plain wordsIn rats, peripheral oxytocin decreased dopamine disappearance in the midbrain after alpha-MPT.
Peptide
Oxytocin
Outcome
DecreaseMesencephalic dopamine disappearance after alpha-MPT
Study
ratn: not reported in source
brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · peripheral injectionAs given in this study (rat).
Source sentences
Summary
Peripheral injection of OXT facilitated the alpha-MPT-induced disappearance of noradrenaline (NA) in the mesencephalon. Dopamine (DA) disappearance was inhibited in the mesencephalon and facilitated in the striatum.
Report a problemFND-0613549502
03AnimalAnimal study (in vivo)Mechanism
In rats, oxytocin facilitated striatal dopamine disappearance when injected after alpha-MPT treatment.
In plain wordsIn rats, oxytocin given after alpha-MPT increased striatal dopamine disappearance.
Peptide
Oxytocin
Outcome
IncreaseStriatal dopamine disappearance after alpha-MPT
Study
ratn: not reported in source
brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · peripheral injectionAs given in this study (rat).
Source sentences
Summary
Peripheral injection of OXT facilitated the alpha-MPT-induced disappearance of noradrenaline (NA) in the mesencephalon. Dopamine (DA) disappearance was inhibited in the mesencephalon and facilitated in the striatum. The accelerated striatal DA disappearance was not observed if the peptide was given…
Report a problemFND-0613549503
04AnimalAnimal study (in vivo)Mechanism
In rats, intraventricular oxytocin decreased mesencephalic dopamine disappearance.
In plain wordsIn rats, oxytocin injected into the brain decreased dopamine disappearance in the midbrain.
Peptide
Oxytocin
Outcome
DecreaseMesencephalic dopamine disappearance after central oxytocin
Study
ratn: not reported in source
brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · intraventricular injectionAs given in this study (rat).
Source sentences
Summary
Intraventricular injection of OXT or des-glycinamide-oxytocin (DG-OXT) caused a decrease in the DA disappearance in the mesencephalon
Report a problemFND-0613549504
05AnimalAnimal study (in vivo)Mechanism
In rats, oxytocin given together with alpha-MPT did not accelerate striatal dopamine disappearance.
In plain wordsIn rats, oxytocin given with alpha-MPT did not increase striatal dopamine disappearance.
Peptide
Oxytocin
Outcome
No significant changeStriatal dopamine disappearance with simultaneous oxytocin and alpha-MPT
Study
ratn: not reported in source
brain
Comparator
Oxytocin injected after alpha-MPT treatment
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · peripheral injectionAs given in this study (rat).
Source sentences
Summary
Peripheral injection of OXT facilitated the alpha-MPT-induced disappearance of noradrenaline (NA) in the mesencephalon. Dopamine (DA) disappearance was inhibited in the mesencephalon and facilitated in the striatum. The accelerated striatal DA disappearance was not observed if the peptide was given…
Report a problemFND-0613549506

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats, central anti-oxytocin serum accelerated mesencephalic dopamine disappearance.
In plain wordsIn rats, anti-oxytocin serum given into the brain increased dopamine disappearance in the midbrain.
Peptide
Oxytocin
Outcome
IncreaseMesencephalic dopamine disappearance after anti-oxytocin serum
Study
ratn: not reported in source
brain
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Intraventricular injection of OXT or des-glycinamide-oxytocin (DG-OXT) caused a decrease in the DA disappearance in the mesencephalon, whereas central administration of anti-oxytocin serum (anti-OXT) accelerated the DA disappearance in the same region.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0613549505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

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