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Study · Animal study (in vivo) · mouse · 1983

4 results

Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on morphine-induced antinociception and brain mu, delta and kappa opiate receptors.

Bhargava HN, Pandey RN, Matwyshyn GA

Life sciences1 May 1983Cited by 2 (Europe PMC)

PMID6133201 (opens in a new tab)DOI10.1016/0024-3205(83)90097-8 (opens in a new tab)PepBankPUB-06133201
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, PLG pretreatment did not affect morphine antinociception compared with vehicle.

    In plain wordsIn mice, PLG did not change morphine pain relief compared with vehicle.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMorphine antinociception
    Study

    mousen: not reported in source

    Morphine-induced antinociception
    Comparator
    Vehicle
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1, 2, and 4 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Subcutaneous administration of either of the above peptides (1, 2, and 4 mg/kg) 10 min prior to the injection of morphine did not affect morphine-induced antinociception as evidenced by the identical ED50 values of morphine in vehicle and peptide treated groups.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide and cyclo (leucyl-glycine) on morphine-induced antinociception in mice and on in vitro binding of 3H-ligands for opiate receptor subtypes (mu, delta and kappa) in the mouse brain homogenate were determined.
  2. 02LabIn vitro (cell-free)Activity measurement

    In mouse brain homogenate, PLG did not affect mu receptor ligand binding.

    In plain wordsIn lab tests, PLG did not change ligand binding to mouse mu receptors.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMu receptor ligand binding
    Study

    mousen: not reported in source

    Mouse brain homogenate
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The binding of 3H-dihydromorphine and 3H-naloxone (mu receptors), 3H-D-Ala2-D-Leu5-enkephalin (delta receptors), and 3H-ethylketocyclazocine (kappa receptors) to opiate receptors in the mouse brain homogenate was also unaffected by both the peptides over a large concentration range.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide and cyclo (leucyl-glycine) on morphine-induced antinociception in mice and on in vitro binding of 3H-ligands for opiate receptor subtypes (mu, delta and kappa) in the mouse brain homogenate were determined.
  3. 03LabIn vitro (cell-free)Activity measurement

    In mouse brain homogenate, PLG did not affect delta receptor ligand binding.

    In plain wordsIn lab tests, PLG did not change ligand binding to mouse delta receptors.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeDelta receptor ligand binding
    Study

    mousen: not reported in source

    Mouse brain homogenate
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The binding of 3H-dihydromorphine and 3H-naloxone (mu receptors), 3H-D-Ala2-D-Leu5-enkephalin (delta receptors), and 3H-ethylketocyclazocine (kappa receptors) to opiate receptors in the mouse brain homogenate was also unaffected by both the peptides over a large concentration range.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide and cyclo (leucyl-glycine) on morphine-induced antinociception in mice and on in vitro binding of 3H-ligands for opiate receptor subtypes (mu, delta and kappa) in the mouse brain homogenate were determined.
  4. 04LabIn vitro (cell-free)Activity measurement

    In mouse brain homogenate, PLG did not affect kappa receptor ligand binding.

    In plain wordsIn lab tests, PLG did not change ligand binding to mouse kappa receptors.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeKappa receptor ligand binding
    Study

    mousen: not reported in source

    Mouse brain homogenate
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The binding of 3H-dihydromorphine and 3H-naloxone (mu receptors), 3H-D-Ala2-D-Leu5-enkephalin (delta receptors), and 3H-ethylketocyclazocine (kappa receptors) to opiate receptors in the mouse brain homogenate was also unaffected by both the peptides over a large concentration range.
    1 context sentence
    Summary · context
    The effects of prolyl-leucyl-glycinamide and cyclo (leucyl-glycine) on morphine-induced antinociception in mice and on in vitro binding of 3H-ligands for opiate receptor subtypes (mu, delta and kappa) in the mouse brain homogenate were determined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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