Inhibition by L-prolyl-L-leucyl-glycinamide (PLG) of alpha-melanocyte stimulating hormone release from hypothalamic slices.

Scimonelli T, Celis ME

Peptides1 Nov 1982Cited by 9 (Europe PMC)

PMID6132363DOI10.1016/0196-9781(82)90055-9PepBankPUB-06132363

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In rat hypothalamic slices, PLG inhibited spontaneous alpha-MSH release, with greater inhibition at the lowest dose.
In plain wordsIn lab tests, PLG reduced spontaneous alpha-MSH release from rat hypothalamic slices, with greater inhibition at the lowest dose.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseSpontaneous alpha-MSH release
Study
ratn: not reported in source
Male rat hypothalamic slices
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0.04 to 1 microgramAs given in this study (rat).
Source sentences
Summary
Both spontaneous and potassium-induced release were inhibited in a dose-response manner by the tripeptide Pro-Leu-Gly-NH2 (PLG, or MIF-1); 0.04 microgram to 1 microgram PLG inhibited the alpha-MSH release but the lowest dose demonstrated a greater inhibitory effect;
1 context sentence(design, population, supporting numbers)
Summary · context
Release of alpha-MSH from male rat hypothalamic slices was studied using a sensitive bioassay (1-2 pg).
Report a problemFND-0613236301
02LabEx vivo tissueActivity measurement
In rat hypothalamic slices, PLG inhibited potassium-induced alpha-MSH release, with greater inhibition at the lowest dose.
In plain wordsIn lab tests, PLG reduced potassium-induced alpha-MSH release from rat hypothalamic slices, with greater inhibition at the lowest dose.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreasePotassium-induced alpha-MSH release
Study
ratn: not reported in source
Male rat hypothalamic slices
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0.04 to 1 microgramAs given in this study (rat).
Source sentences
Summary
Both spontaneous and potassium-induced release were inhibited in a dose-response manner by the tripeptide Pro-Leu-Gly-NH2 (PLG, or MIF-1); 0.04 microgram to 1 microgram PLG inhibited the alpha-MSH release but the lowest dose demonstrated a greater inhibitory effect;
1 context sentence(design, population, supporting numbers)
Summary · context
Release of alpha-MSH from male rat hypothalamic slices was studied using a sensitive bioassay (1-2 pg).
Report a problemFND-0613236302
03LabEx vivo tissueActivity measurement
In rat hypothalamic slices, high PLG concentrations did not modify spontaneous alpha-MSH release.
In plain wordsIn lab tests, high PLG concentrations did not change spontaneous alpha-MSH release from rat hypothalamic slices.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeSpontaneous alpha-MSH release at high concentrations
Study
ratn: not reported in source
Male rat hypothalamic slices
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
high concentrationsAs given in this study (rat).
Source sentences
Summary
high concentrations of PLG, on the other hand, did not modify either spontaneous or potassium-evoked alpha-MSH release from the slices.
1 context sentence(design, population, supporting numbers)
Summary · context
Release of alpha-MSH from male rat hypothalamic slices was studied using a sensitive bioassay (1-2 pg).
Report a problemFND-0613236303
04LabEx vivo tissueActivity measurement
In rat hypothalamic slices, high PLG concentrations did not modify potassium-induced alpha-MSH release.
In plain wordsIn lab tests, high PLG concentrations did not change potassium-induced alpha-MSH release from rat hypothalamic slices.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changePotassium-induced alpha-MSH release at high concentrations
Study
ratn: not reported in source
Male rat hypothalamic slices
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
high concentrationsAs given in this study (rat).
Source sentences
Summary
high concentrations of PLG, on the other hand, did not modify either spontaneous or potassium-evoked alpha-MSH release from the slices.
1 context sentence(design, population, supporting numbers)
Summary · context
Release of alpha-MSH from male rat hypothalamic slices was studied using a sensitive bioassay (1-2 pg).
Report a problemFND-0613236304

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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