MIF-1 does not act like naloxone in antagonizing the cardiovascular activity of leucine-enkephalin in the conscious dog.

Sander GE, Kastin AJ, Giles TD

Pharmacology, biochemistry, and behavior1 Dec 1982Cited by 15 (Europe PMC)

PMID6131437DOI10.1016/0091-3057(82)90139-3PepBankPUB-06131437

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs, MIF‑1 did not affect Leu5-enkephalin-induced heart rate elevation.
In plain wordsIn conscious dogs, MIF‑1 did not change the heart rate increase from Leu5-enkephalin.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeEnkephalin-induced heart rate elevation
Study
dogn: not reported in source
Chronically instrumented dogs
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Although naloxone inhibits both the elevations of heart rate and blood pressure produced by IV Leu5-ENK in the conscious state and the depressions in these variables produced by Leu5-ENK after pentobarbital anesthesia, MIF-1 has no effect upon the Leu5-ENK response in either state.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the interactions of MIF-1 with Leu5-enkephalin (Leu5-ENK) in the conscious, chronically instrumented dog.
Report a problemFND-0613143701
02AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs, MIF‑1 did not affect Leu5-enkephalin-induced blood pressure elevation.
In plain wordsIn conscious dogs, MIF‑1 did not change the blood pressure increase from Leu5-enkephalin.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeEnkephalin-induced blood pressure elevation
Study
dogn: not reported in source
Chronically instrumented dogs
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Although naloxone inhibits both the elevations of heart rate and blood pressure produced by IV Leu5-ENK in the conscious state and the depressions in these variables produced by Leu5-ENK after pentobarbital anesthesia, MIF-1 has no effect upon the Leu5-ENK response in either state.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the interactions of MIF-1 with Leu5-enkephalin (Leu5-ENK) in the conscious, chronically instrumented dog.
Report a problemFND-0613143702
03AnimalAnimal study (in vivo)Efficacy outcome
In pentobarbital-anesthetized dogs, MIF‑1 did not affect Leu5-enkephalin-induced heart rate depression.
In plain wordsIn dogs under pentobarbital anesthesia, MIF‑1 did not change the heart rate decrease from Leu5-enkephalin.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeEnkephalin-induced heart rate depression
Study
dogn: not reported in source
Chronically instrumented dogs
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Although naloxone inhibits both the elevations of heart rate and blood pressure produced by IV Leu5-ENK in the conscious state and the depressions in these variables produced by Leu5-ENK after pentobarbital anesthesia, MIF-1 has no effect upon the Leu5-ENK response in either state.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the interactions of MIF-1 with Leu5-enkephalin (Leu5-ENK) in the conscious, chronically instrumented dog.
Report a problemFND-0613143703
04AnimalAnimal study (in vivo)Efficacy outcome
In pentobarbital-anesthetized dogs, MIF‑1 did not affect Leu5-enkephalin-induced blood pressure depression.
In plain wordsIn dogs under pentobarbital anesthesia, MIF‑1 did not change the blood pressure decrease from Leu5-enkephalin.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeEnkephalin-induced blood pressure depression
Study
dogn: not reported in source
Chronically instrumented dogs
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Although naloxone inhibits both the elevations of heart rate and blood pressure produced by IV Leu5-ENK in the conscious state and the depressions in these variables produced by Leu5-ENK after pentobarbital anesthesia, MIF-1 has no effect upon the Leu5-ENK response in either state.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the interactions of MIF-1 with Leu5-enkephalin (Leu5-ENK) in the conscious, chronically instrumented dog.
Report a problemFND-0613143704
05AnimalAnimal study (in vivo)Efficacy outcome
In conscious dogs, MIF‑1 appeared to raise mean arterial pressure.
In plain wordsIn conscious dogs, MIF‑1 appeared to increase mean arterial pressure.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseMean arterial pressure
Study
dogn: not reported in source
Chronically instrumented dogs
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
However, both naloxone and MIF-1 seem to raise mean arterial pressure in the conscious dog.
1 context sentence(design, population, supporting numbers)
Summary · context
We have studied the interactions of MIF-1 with Leu5-enkephalin (Leu5-ENK) in the conscious, chronically instrumented dog.
Report a problemFND-0613143705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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