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Study · Animal study (in vivo) · carassius auratus · 1982

2 results

Similar antagonism of morphine analgesia by MIF-1 and naloxone in Carassius auratus.

Ehrensing RH, Michell GF, Kastin AJ

Pharmacology, biochemistry, and behavior1 Oct 1982Cited by 43 (Europe PMC)

PMID6129644 (opens in a new tab)DOI10.1016/0091-3057(82)90358-6 (opens in a new tab)PepBankPUB-06129644
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In goldfish, MIF‑1 significantly reduced morphine analgesia compared with the diluent control group.

    In plain wordsIn goldfish, MIF‑1 reduced morphine's pain relief compared with the diluent control group.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseMorphine analgesia to electric shock
    Study

    Carassius auratusn: not reported in source

    goldfish with morphine-induced analgesia
    Comparator
    diluent control with morphine
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.001, 0.01, 0.1, 1.0 and 10.0 mg/kg · intracranialAs given in this study (Carassius auratus).

    Source sentences

    Summary
    Both MIF-1 and naloxone were found to significantly reduce the analgesic effects of morphine when compared to the diluent control group.
    2 context sentences
    Summary · context
    Prolyl-leucyl-glycinamide (MIF-1), the C-terminal tripeptide of oxytocin, and naloxone were administered intracranially (IC) to goldfish (Carassius auratus) in doses of 0.001, 0.01, 0.1, 1.0 and 10.0 mg/kg and compared to a diluent control group for their ability to reduce the effects of morphine (3…
    Summary · context
    Threshold levels of pain were determined by the voltage necessary to produce an agitated swimming response (ASR).
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In goldfish, MIF‑1 and naloxone showed similar apparent sine-wave dose-response curves at 20 minutes and across the 150-minute experiment.

    In plain wordsIn goldfish, MIF‑1 and naloxone showed similar dose-response patterns at 20 minutes and across the 150-minute experiment.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    Not applicableAnalgesia antagonism dose-response pattern
    Study

    Carassius auratusn: not reported in source

    goldfish with morphine-induced analgesia
    Comparator
    naloxone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.001, 0.01, 0.1, 1.0 and 10.0 mg/kg · intracranialAs given in this study (Carassius auratus).

    Source sentences

    Summary
    Similar dose-response curves in an apparent sine-wave pattern were noted with both MIF-1 and naloxone when comparisons were made both at 20 minutes after administration of morphine and over the entire 150 minutes of the experiment.
    2 context sentences
    Summary · context
    Prolyl-leucyl-glycinamide (MIF-1), the C-terminal tripeptide of oxytocin, and naloxone were administered intracranially (IC) to goldfish (Carassius auratus) in doses of 0.001, 0.01, 0.1, 1.0 and 10.0 mg/kg and compared to a diluent control group for their ability to reduce the effects of morphine (3…
    Summary · context
    Threshold levels of pain were determined by the voltage necessary to produce an agitated swimming response (ASR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 9Current

    28 Oct 2026, 02:03 UTC

    The same notice was added 6 times, first on 22 Oct 2026, 02:26 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    11 Oct 2026, 20:03 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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