Release of vasoactive intestinal peptide from rat brain slices by various depolarizing agents.

Besson J, Rotsztejn W, Poussin B, Lhiaubet AM, Rosselin G

Neuroscience letters1 Mar 1982Cited by 21 (Europe PMC)

PMID6123097DOI10.1016/0304-3940(82)90071-4PepBankPUB-06123097

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueMechanism
In rat cortical and amygdala slices, basal VIP release was of the same order in both structures and under 0.1% of tissue content per minute.
In plain wordsIn lab tests on rat brain slices, the tissue's own VIP leaked out slowly at rest, in similar amounts in both areas.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableBasal VIP release from brain slices
Study
ratn: not reported in source
brain cortical and amygdala slices
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
basal VIP release
< 0.1 % of tissue content per minute
cortex and amygdala
Source sentences
Summary
The basal release of VIP observed is of the same order of magnitude for both structures and represents less than 0.1% of the tissue content per minute measured by a specific radioimmunoassay.
1 context sentence(design, population, supporting numbers)
Summary · context
The release of vasoactive intestinal peptide (VIP) from rat brain cortical and amygdala slices was studied by using various depolarizing agents such as potassium (K+), veratridine (VER) and batrachotoxin (BTX).
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0612309701
02LabEndogenous levelEx vivo tissueMechanism
In rat cortical and amygdala slices, maximal stimulation with potassium, veratridine and batrachotoxin gave a mean 3-fold increase above basal VIP release.
In plain wordsIn lab tests on rat brain slices, depolarizing agents made the tissue release about three times more of its own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseDepolarizing agent-induced VIP release
Study
ratn: not reported in source
brain cortical and amygdala slices
Outcome group
Endogenous peptide levels · Nervous system and cognition
Measurements
VIP release above basal
3 fold
cortex and amygdala, maximal stimulation
Source sentences
Summary
Maximal stimulation obtained with 56 mMK+, 50 microM VER and 1 microM BTX corresponds to a mean 3-fold increase above the basal release of VIP in both cortex and amygdala.
1 context sentence(design, population, supporting numbers)
Summary · context
The release of vasoactive intestinal peptide (VIP) from rat brain cortical and amygdala slices was studied by using various depolarizing agents such as potassium (K+), veratridine (VER) and batrachotoxin (BTX).
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0612309702
03LabEndogenous levelEx vivo tissueMechanism
In rat brain slices, removing calcium from the medium suppressed the potassium-induced release of VIP.
In plain wordsIn lab tests on rat brain slices, release of the body's own VIP triggered by potassium stopped when calcium was left out.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseCalcium dependence of potassium-induced VIP release
Study
ratn: not reported in source
brain cortical and amygdala slices
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
When the incubation medium did not contain any calcium, the action of potassium on the release of VIP was suppressed.
1 context sentence(design, population, supporting numbers)
Summary · context
The release of vasoactive intestinal peptide (VIP) from rat brain cortical and amygdala slices was studied by using various depolarizing agents such as potassium (K+), veratridine (VER) and batrachotoxin (BTX).
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0612309703
04LabEndogenous levelEx vivo tissueMechanism
In rat brain slices, tetrodotoxin inhibited the veratridine- and batrachotoxin-induced release of VIP.
In plain wordsIn lab tests on rat brain slices, tetrodotoxin blocked release of the body's own VIP triggered by veratridine and batrachotoxin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseTetrodotoxin effect on veratridine- and batrachotoxin-induced VIP release
Study
ratn: not reported in source
brain cortical and amygdala slices
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
When tetrodotoxin (1 microM) was added to the incubation medium, the veratridine- and batrachotoxin-induced release of VIP was inhibited whereas K+-induced release was unaffected.
1 context sentence(design, population, supporting numbers)
Summary · context
The release of vasoactive intestinal peptide (VIP) from rat brain cortical and amygdala slices was studied by using various depolarizing agents such as potassium (K+), veratridine (VER) and batrachotoxin (BTX).
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0612309704
05LabEndogenous levelEx vivo tissueMechanism
In rat brain slices, tetrodotoxin did not affect the potassium-induced release of VIP.
In plain wordsIn lab tests on rat brain slices, tetrodotoxin did not change release of the body's own VIP triggered by potassium.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeTetrodotoxin effect on potassium-induced VIP release
Study
ratn: not reported in source
brain cortical and amygdala slices
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
When tetrodotoxin (1 microM) was added to the incubation medium, the veratridine- and batrachotoxin-induced release of VIP was inhibited whereas K+-induced release was unaffected.
1 context sentence(design, population, supporting numbers)
Summary · context
The release of vasoactive intestinal peptide (VIP) from rat brain cortical and amygdala slices was studied by using various depolarizing agents such as potassium (K+), veratridine (VER) and batrachotoxin (BTX).
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0612309705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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