Rabbit liver microsomal metabolism of enclomiphene.

Ruenitz PC

Drug metabolism and disposition: the biological fate of chemicals1 Sept 1981Cited by 8 (Europe PMC)

PMID6117445DOI10.1016/s0090-9556(25)06175-6PepBankPUB-06117445

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cell-free)Pharmacokinetics
In rabbit liver microsomes with NADPH, enclomiphene produced two metabolites, EC-1 and EC-2.
In plain wordsIn lab tests, rabbit liver microsomes converted enclomiphene into two metabolites.
Peptide
Enclomiphene
Outcome
Not applicableMicrosomal metabolite formation
Study
rabbitn: not reported in source
Rabbit liver microsomes
Outcome group
Pharmacokinetics · Liver
Studied dose
Dose not stated
Source sentences
Summary
Incubation of EC with microsomes in the presence of NADPH gave two metabolites, EC-1 and EC-2, as determined by thin-layer chromatography (TLC).
1 context sentence(design, population, supporting numbers)
Summary · context
Metabolism of the triarylethylene antiestrogen enclomiphene (EC) has been studied in rabbit liver.
Report a problemFND-0611744501
02LabIn vitro (cell-free)Pharmacokinetics
In rabbit liver microsomes, enclomiphene metabolite EC-1 matched synthetic desethylenclomiphene by mass spectrometry and chromatography.
In plain wordsIn lab tests, an enclomiphene metabolite from rabbit liver matched desethylenclomiphene.
Peptide
Enclomiphene
Outcome
Not applicableDesethylenclomiphene metabolite identification
Study
rabbitn: not reported in source
Rabbit liver microsomes
Outcome group
Pharmacokinetics · Liver
Studied dose
Dose not stated
Source sentences
Summary
EC-1 had mass-spectral features that were identical to those of synthetic desethylenclomiphene, and was indistinguishable from this compound by TLC and gas-liquid chromatography (GLC).
1 context sentence(design, population, supporting numbers)
Summary · context
Metabolism of the triarylethylene antiestrogen enclomiphene (EC) has been studied in rabbit liver.
Report a problemFND-0611744502
03LabIn vitro (cell-free)Pharmacokinetics
In rabbit liver microsomes, enclomiphene metabolite EC-2 matched synthetic 4-hydroxyclomiphene and differed chromatographically from 3-hydroxyclomiphene.
In plain wordsIn lab tests, another enclomiphene metabolite matched 4-hydroxyclomiphene and differed from 3-hydroxyclomiphene.
Peptide
Enclomiphene
Outcome
Not applicable4-hydroxyclomiphene metabolite identification
Study
rabbitn: not reported in source
Rabbit liver microsomes
Outcome group
Pharmacokinetics · Liver
Studied dose
Dose not stated
Source sentences
Summary
EC-2 was similarly identical to synthetic 4-hydroxyclomiphene, but was separable from 3-hydroxyclomiphene by TLC ang GLC.
1 context sentence(design, population, supporting numbers)
Summary · context
Metabolism of the triarylethylene antiestrogen enclomiphene (EC) has been studied in rabbit liver.
Report a problemFND-0611744503

Studies that did not test the peptide alone1

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

04LabNot a test of Enclomiphene aloneIn vitro (cell-free)Activity measurement
In rabbit liver metabolism analysis, EC-2 methyl ether matched 4-methoxyclomiphene but not 4'-methoxyclomiphene by gas-liquid chromatography.
In plain wordsIn lab tests, the enclomiphene metabolite methyl ether matched 4-methoxyclomiphene but not its alternative isomer.
Peptide
Enclomiphene
Outcome
Not applicableMetabolite methyl ether identification
Study
rabbitn: not reported in source
Rabbit liver microsomes
Outcome group
Pharmacokinetics · Liver
Source sentences
Summary
EC-2 methyl ether was homogeneous with 4-methoxyclomiphene, but not with 4'-methoxyclomiphene, in GLC.
1 context sentence(design, population, supporting numbers)
Summary · context
Metabolism of the triarylethylene antiestrogen enclomiphene (EC) has been studied in rabbit liver.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0611744504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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