Somatostatin action on insulin secretion induced by chicken and porcine vasoactive intestinal peptide in the perfused rat pancreas.

Arilla E, Prieto JC, López-Martínez JM, Goberna R

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme1 Jun 1981Cited by 2 (Europe PMC)

PMID6114916DOI10.1055/s-2007-1019255PepBankPUB-06114916

Publisher page PubMedAsk about this study

Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In the isolated perfused rat pancreas, 750 pM porcine VIP markedly enhanced insulin release in response to 5.5 or 16.7 mM glucose, and 250 pM was still effective.
In plain wordsIn lab tests on perfused rat pancreas, porcine VIP clearly increased glucose-induced insulin release, even at a lower concentration.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseGlucose-induced insulin release with porcine VIP
Study
ratn: not reported in source
isolated perfused pancreas with duodenal exclusion
Comparator
Glucose alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
750 pMAs given in this study (rat).
Measurements
VIP concentration
750 pM
porcine VIP, effective dose
VIP concentration
250 pM
porcine VIP, still effective
Source sentences
Summary
The insulin response to 5.5 or 16.7 mM glucose was markedly enhanced by 750 pM porcine VIP and a concentration of 250 pM was still effective.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated perfused rat pancreas with duodenal exclusion was used to study the stimulation of glucose-induced insulin release in response to chicken and porcine vasoactive intestinal peptide (VIP).
Report a problemFND-0611491601
02LabEx vivo tissueEfficacy outcome
In the isolated perfused rat pancreas, chicken VIP at 250 pM had slightly higher potency than porcine VIP at both glucose concentrations.
In plain wordsIn lab tests on perfused rat pancreas, chicken VIP raised insulin release slightly more than porcine VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePotency of chicken VIP versus porcine VIP on insulin release
Study
ratn: not reported in source
isolated perfused pancreas with duodenal exclusion
Comparator
Porcine VIP
Outcome group
Glycemic control · Metabolic and weight
Studied dose
250 pMAs given in this study (rat).
Measurements
VIP concentration
250 pM
chicken VIP
Source sentences
Summary
At 250 pM, chicken VIp exhibited a slightly higher potency than porcine VIP at both glucose concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated perfused rat pancreas with duodenal exclusion was used to study the stimulation of glucose-induced insulin release in response to chicken and porcine vasoactive intestinal peptide (VIP).
Report a problemFND-0611491602
03LabEx vivo tissueEfficacy outcome
In the isolated perfused rat pancreas, the effect of porcine VIP disappeared immediately after VIP removal, but the effect of chicken VIP persisted for an additional 8-10 minutes.
In plain wordsIn lab tests on perfused rat pancreas, the effect of chicken VIP lasted several minutes after removal, while porcine VIP stopped acting at once.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedDuration of VIP effect on insulin release after VIP removal
Study
ratn: not reported in source
isolated perfused pancreas with duodenal exclusion
Comparator
Porcine VIP
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Measurements
Persistence of effect
8 to 10 min
chicken VIP after removal
Source sentences
Summary
The main difference between the two peptides was that the effect of porcine VIP disappeared immediately after the peptide suppression but tha of chicken VIP persisted for an additional period of 8-10 min.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated perfused rat pancreas with duodenal exclusion was used to study the stimulation of glucose-induced insulin release in response to chicken and porcine vasoactive intestinal peptide (VIP).
Report a problemFND-0611491603

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In the isolated perfused rat pancreas, somatostatin at 10 ng/ml blocked the stimulatory effect of both VIP molecules on glucose-induced insulin secretion.
In plain wordsIn lab tests on perfused rat pancreas, somatostatin blocked the insulin-raising effect that VIP had on its own.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSomatostatin block of VIP-stimulated insulin secretion
Study
ratn: not reported in source
isolated perfused pancreas with duodenal exclusion
Comparator
VIP without somatostatin
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Somatostatin (10 ng/ml) blocked the stimulatory effect of both VIP molecules on glucose-induced insulin secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated perfused rat pancreas with duodenal exclusion was used to study the stimulation of glucose-induced insulin release in response to chicken and porcine vasoactive intestinal peptide (VIP).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0611491604
05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In the isolated perfused rat pancreas, after VIP and somatostatin were removed, insulin release rose above the level with glucose alone for the avian peptide but not for porcine VIP.
In plain wordsIn lab tests on perfused rat pancreas, after both peptides were removed, insulin rose above the glucose-alone level for chicken VIP but not porcine VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedInsulin release after removal of VIP and somatostatin
Study
ratn: not reported in source
isolated perfused pancreas with duodenal exclusion
Comparator
Glucose alone
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
After suppression of VIP and somatostatin from the perfusion medium, insulin release increased to levels higher than those with glucose alone in the case of the avian peptide, but not in that porcine VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated perfused rat pancreas with duodenal exclusion was used to study the stimulation of glucose-induced insulin release in response to chicken and porcine vasoactive intestinal peptide (VIP).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0611491605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.