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Study · In vitro (cell-free) · rat · 1984

3 results

Interaction of non-steroidal antiestrogens with dopamine receptor binding.

Hiemke C, Ghraf R

Journal of steroid biochemistry1 Dec 1984Cited by 30 (Europe PMC)

PMID6098784 (opens in a new tab)DOI10.1016/0022-4731(84)90028-1 (opens in a new tab)PepBankPUB-06098784
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In rat striatal membrane assays, enclomiphene competitively inhibited labeled spiroperidol binding.

    In plain wordsIn lab tests with rat brain membranes, enclomiphene competitively inhibited labeled spiroperidol binding.

    Peptide
    Enclomiphene
    Outcome
    DecreaseCompetitive inhibition of spiroperidol binding
    Study

    ratn: not reported in source

    Rat brain striatal membrane preparations
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The non-steroidal triphenylethylene-type antiestrogens with an amine side chain--enclomiphene, nitromifene, tamoxifen and zuclomiphene--were found to be competitive inhibitors of [3H]spiroperidol (Kd = 0.12 nM; Bmax = 101 fmol/mg protein) and [3H]domperidone (Kd = 0.62 nM; Bmax = 86 fmol/mg protein)…
    1 context sentence
    Summary · context
    The ability of various estrogen antagonists and agonists to compete with [3H]spiroperidol, [3H]domperidone, [3H]dihydroalprenolol, [3H]dihydroergocryptine, [3H]dopamine or [3H]5-hydroxytryptamine for binding to membrane preparations from rat brain tissue was tested.
  2. 02LabIn vitro (cell-free)Activity measurement

    In rat striatal membrane assays, enclomiphene competitively inhibited labeled domperidone binding.

    In plain wordsIn lab tests with rat brain membranes, enclomiphene competitively inhibited labeled domperidone binding.

    Peptide
    Enclomiphene
    Outcome
    DecreaseCompetitive inhibition of domperidone binding
    Study

    ratn: not reported in source

    Rat brain striatal membrane preparations
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The non-steroidal triphenylethylene-type antiestrogens with an amine side chain--enclomiphene, nitromifene, tamoxifen and zuclomiphene--were found to be competitive inhibitors of [3H]spiroperidol (Kd = 0.12 nM; Bmax = 101 fmol/mg protein) and [3H]domperidone (Kd = 0.62 nM; Bmax = 86 fmol/mg protein)…
    1 context sentence
    Summary · context
    The ability of various estrogen antagonists and agonists to compete with [3H]spiroperidol, [3H]domperidone, [3H]dihydroalprenolol, [3H]dihydroergocryptine, [3H]dopamine or [3H]5-hydroxytryptamine for binding to membrane preparations from rat brain tissue was tested.

Studies that did not test the peptide alone1

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

  1. 03LabNot a test of Enclomiphene aloneIn vitro (cell-free)Activity measurement

    In rat striatal membrane assays, the antiestrogen group including enclomiphene had Ki values ranging from 4-12 microM.

    In plain wordsIn lab tests with rat brain membranes, the antiestrogen group including enclomiphene had the reported range of binding inhibition constants.

    Peptide
    Enclomiphene
    Outcome
    Not applicableInhibition constant range
    Study

    ratn: not reported in source

    Rat brain striatal membrane preparations
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Ki
    4 to 12 microM
    antiestrogen group including enclomiphene

    Source sentences

    Summary
    The Ki values ranged from 4-12 microM.
    2 context sentences
    Summary · context
    The non-steroidal triphenylethylene-type antiestrogens with an amine side chain--enclomiphene, nitromifene, tamoxifen and zuclomiphene--were found to be competitive inhibitors of [3H]spiroperidol (Kd = 0.12 nM; Bmax = 101 fmol/mg protein) and [3H]domperidone (Kd = 0.62 nM; Bmax = 86 fmol/mg protein)…
    Summary · context
    The ability of various estrogen antagonists and agonists to compete with [3H]spiroperidol, [3H]domperidone, [3H]dihydroalprenolol, [3H]dihydroergocryptine, [3H]dopamine or [3H]5-hydroxytryptamine for binding to membrane preparations from rat brain tissue was tested.

    In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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