Lack of response in the release of oxytocin and vasopressin from isolated neurohypophyses to dopamine, met-enkephalin and leu-enkephalin.

Pitzel L, König A

Experimental brain research1 Jan 1984Cited by 8 (Europe PMC)

PMID6090193DOI10.1007/bf00236277PepBankPUB-06090193

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes from untreated rats, dopamine did not change neurohypophyseal hormone release, oxytocin included.
In plain wordsIn rat pituitary lobes in the lab, dopamine did not change release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release after dopamine, untreated rats
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
neurohypophyseal hormone release was not affected by dopamine, neither from lobes of untreated rats
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019301
02LabEndogenous levelEx vivo tissueMechanism
In isolated neurointermediate lobes from dopamine-deficient rats (pretreated with alpha-methyl-p-tyrosine-methylester), dopamine did not change neurohypophyseal hormone release.
In plain wordsIn rat pituitary lobes from dopamine-deficient rats, dopamine did not change release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release after dopamine, dopamine-deficient rats
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
neurohypophyseal hormone release was not affected by dopamine, neither from lobes of untreated rats nor from those of rats with dopamine-deficiency
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019302
03LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes, the dopamine antagonist metoclopramide did not alter neurohypophyseal hormone release.
In plain wordsIn rat pituitary lobes in the lab, metoclopramide did not change release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release after metoclopramide
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Likewise, metoclopramide, a dopamine antagonist, was unable to alter the neurohypophyseal hormone release.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019303
04LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes, met-enkephalin did not influence spontaneous oxytocin release.
In plain wordsIn rat pituitary lobes in the lab, met-enkephalin did not change spontaneous release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeSpontaneous oxytocin release after met-enkephalin
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Our results also indicate that the opioid peptides met-enkephalin and leu-enkephalin do not influence spontaneous or ouabain-stimulated oxytocin and vasopressin release, which is in accordance with our findings that naloxone under our experimental conditions is also ineffective.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019304
05LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes, leu-enkephalin did not influence spontaneous oxytocin release.
In plain wordsIn rat pituitary lobes in the lab, leu-enkephalin did not change spontaneous release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeSpontaneous oxytocin release after leu-enkephalin
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Our results also indicate that the opioid peptides met-enkephalin and leu-enkephalin do not influence spontaneous or ouabain-stimulated oxytocin and vasopressin release, which is in accordance with our findings that naloxone under our experimental conditions is also ineffective.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019305
06LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes, naloxone was ineffective on neurohypophyseal hormone release under the experimental conditions.
In plain wordsIn rat pituitary lobes in the lab, naloxone did not change release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release after naloxone
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
naloxone under our experimental conditions is also ineffective.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019306
07LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes, met-enkephalin did not influence ouabain-stimulated oxytocin release.
In plain wordsIn rat pituitary lobes in the lab, met-enkephalin did not change ouabain-stimulated release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOuabain-stimulated oxytocin release after met-enkephalin
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Our results also indicate that the opioid peptides met-enkephalin and leu-enkephalin do not influence spontaneous or ouabain-stimulated oxytocin and vasopressin release, which is in accordance with our findings that naloxone under our experimental conditions is also ineffective.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019307
08LabEndogenous levelEx vivo tissueMechanism
In isolated rat neurointermediate lobes, leu-enkephalin did not influence ouabain-stimulated oxytocin release.
In plain wordsIn rat pituitary lobes in the lab, leu-enkephalin did not change ouabain-stimulated release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOuabain-stimulated oxytocin release after leu-enkephalin
Study
ratn: not reported in source
isolated neurointermediate lobes
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Our results also indicate that the opioid peptides met-enkephalin and leu-enkephalin do not influence spontaneous or ouabain-stimulated oxytocin and vasopressin release, which is in accordance with our findings that naloxone under our experimental conditions is also ineffective.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of dopamine, met-enkephalin and leu-enkephalin on basal and ouabain-stimulated release of oxytocin and vasopressin from isolated neurointermediate lobes.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0609019308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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