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Study · Ex vivo tissue · cattle, rat and guinea pig · 1984

5 results

Cerebral vascular adenylate cyclase: evidence for coupling to receptors for vasoactive intestinal peptide and parathyroid hormone.

Huang M, Rorstad OP

Journal of neurochemistry1 Sept 1984Cited by 53 (Europe PMC)

PMID6086840 (opens in a new tab)DOI10.1111/j.1471-4159.1984.tb12808.x (opens in a new tab)PepBankPUB-06086840
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In cerebral microvessels from rats, guinea-pigs, cattle and pigs, the responsiveness of adenylate cyclase to VIP varied considerably between species.

    In plain wordsIn lab tests on brain vessels from four animal species, the response to VIP differed a lot between species.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    MixedAdenylate cyclase responsiveness to VIP across species
    Study

    rat, guinea pig, cattle, pign: not reported in source

    cerebral microvessels and arteries
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebral microvessels obtained from rats, guinea-pigs, cattle, and pigs all responded potently to bovine (b) PTH-(1-34), whereas considerable between-species variability was observed in the responsiveness to VIP.
    1 context sentence
    Summary · context
    We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries.
  2. 02LabEx vivo tissueActivity measurement

    In a broken-cell preparation of bovine arteries, VIP activated adenylate cyclase with an ED50 of 6.9 nM, with efficacy equal to PHI and greater than bPTH-(1-34).

    In plain wordsIn lab tests on cow arteries, VIP switched on adenylate cyclase at a low dose, as strongly as PHI and more than bPTH-(1-34).

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseActivation of bovine arterial adenylate cyclase by VIP (ED50)
    Study

    cattlen: not reported in source

    cerebral microvessels and arteries
    Comparator
    PHI and bPTH-(1-34)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    ED50
    6.9 nM
    bovine arterial adenylate cyclase

    Source sentences

    Summary
    The ED50 values for activation of bovine arterial adenylate cyclase by VIP, PHI, and bPTH-(1-34) were 6.9 nM, 10 nM, and 100 nM, respectively, with the following order of efficacy: VIP = PHI greater than bPTH-(1-34).
    1 context sentence
    Summary · context
    We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries.
  3. 03LabEx vivo tissueMechanism

    A PTH antagonist did not affect VIP activation of vascular adenylate cyclase in microvessels or arteries, although it inhibited activation by bPTH-(1-34).

    In plain wordsIn lab tests on brain vessels, a PTH blocker did not change how VIP switched on adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeEffect of a PTH antagonist on VIP activation of vascular adenylate cyclase
    Study

    rat, cattlen: not reported in source

    cerebral microvessels and arteries
    Comparator
    PTH antagonist
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The PTH antagonist, [Nle8, Nle18, Tyr34]bPTH-(3-34) amide, inhibited bPTH-(1-34) activation of vascular adenylate cyclase but did not affect activation by VIP using either microvessels or arteries.
    1 context sentence
    Summary · context
    We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries.
  4. 04LabEx vivo tissueMechanism

    VIP or PHI had an additive effect with bPTH-(1-34) on vascular adenylate cyclase activity.

    In plain wordsIn lab tests on brain vessels, VIP added to the effect of bPTH-(1-34) on adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseAdditive effect of VIP and bPTH-(1-34) on vascular adenylate cyclase
    Study

    n: not reported in source

    cerebral microvessels and arteries
    Comparator
    bPTH-(1-34)
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP or PHI demonstrated an additive effect with bPTH-(1-34) on vascular adenylate cyclase activity.
    1 context sentence
    Summary · context
    We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries.
  5. 05LabEx vivo tissueMechanism

    The effects of VIP and PHI on vascular adenylate cyclase were nonadditive with each other.

    In plain wordsIn lab tests on brain vessels, VIP and PHI did not add to each other's effect, which suggests a shared receptor.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeAdditivity of VIP and PHI on vascular adenylate cyclase
    Study

    n: not reported in source

    cerebral microvessels and arteries
    Comparator
    PHI
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the effects of VIP and PHI were nonadditive with each other.
    1 context sentence
    Summary · context
    We have studied the responsiveness of vascular adenylate cyclase to vasoactive intestinal peptide (VIP) and parathyroid hormone (PTH) using preparations of cerebral microvessels and arteries.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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