The effect of administration of human growth hormone on the plasma growth hormone, cortisol, glucose, and free fatty acid response to insulin: evidence for growth hormone autoregulation in man.

Abrams RL, Grumbach MM, Kaplan SL

The Journal of clinical investigation1 Apr 1971Cited by 54 (Europe PMC)

PMID4926262PMCIDPMC292009DOI10.1172/jci106566PepBankPUB-04926262

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanNon-randomized trialMechanism
In healthy men, HGH significantly reduced peak GH response to insulin-induced hypoglycemia at 8 hr after treatment ended.
In plain wordsIn healthy men, HGH reduced the growth hormone response to low blood sugar at 8 hr compared with pretreatment.
Peptide
HGH (somatotropin)
Outcome
DecreasePeak GH response at 8 hr
Study
n = 8
Comparator
Pretreatment control period
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Measurements
Peak GH
4.6 ng/ml
8 hr posttreatment; +/- 1.3
P value
< 0.01 unitless
versus control
Source sentences
Summary
A significant decrease in the maximal peak GH response (n = 8) after insulin-induced hypoglycemia was observed at 8 and 12 hr after HGH administration was terminated with mean peak values for GH of 4.6 +/-1.3 ng/ml and 10.4 +/-1.9 ng/ml, respectively (P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626201
02HumanNon-randomized trialMechanism
In healthy men, HGH significantly reduced peak GH response to insulin-induced hypoglycemia at 12 hr after treatment ended.
In plain wordsIn healthy men, HGH reduced the growth hormone response to low blood sugar at 12 hr compared with pretreatment.
Peptide
HGH (somatotropin)
Outcome
DecreasePeak GH response at 12 hr
Study
n = 8
Comparator
Pretreatment control period
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Measurements
Peak GH
10.4 ng/ml
12 hr posttreatment; +/- 1.9
P value
< 0.01 unitless
versus control
Source sentences
Summary
A significant decrease in the maximal peak GH response (n = 8) after insulin-induced hypoglycemia was observed at 8 and 12 hr after HGH administration was terminated with mean peak values for GH of 4.6 +/-1.3 ng/ml and 10.4 +/-1.9 ng/ml, respectively (P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626202
03HumanNon-randomized trialMechanism
In healthy men after HGH treatment, GH response progressively returned toward control values between 12 and 24 hr.
In plain wordsIn healthy men after HGH treatment, the growth hormone response returned toward control values between 12 and 24 hr.
Peptide
HGH (somatotropin)
Outcome
IncreaseRecovery of GH response
Study
n: not reported in source
Comparator
Suppressed posttreatment response
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
A progressive return to control values was noted between 12 and 24 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626203
04HumanNon-randomized trialEfficacy outcome
In healthy men, fasting glucose after HGH was unchanged from the control period.
In plain wordsIn healthy men, HGH did not change fasting glucose compared with pretreatment.
Peptide
HGH (somatotropin)
Outcome
No significant changeFasting glucose versus pretreatment
Study
n: not reported in source
Comparator
Pretreatment control period
Outcome group
Glycemic control · Metabolic and weight
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
The fasting glucose values were unchanged in the GH-treated group from those of the control period or of the saline-treated controls.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626204
05HumanNon-randomized trialEfficacy outcome
In healthy men, fasting glucose after HGH was unchanged compared with saline-treated controls.
In plain wordsIn healthy men, HGH did not change fasting glucose compared with saline.
Peptide
HGH (somatotropin)
Outcome
No significant changeFasting glucose versus saline
Study
n: not reported in source
Comparator
Saline-treated controls
Outcome group
Glycemic control · Metabolic and weight
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
The fasting glucose values were unchanged in the GH-treated group from those of the control period or of the saline-treated controls.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626205
06HumanNon-randomized trialSafety outcome
In healthy men, insulin resistance was apparent at 8 hr after HGH treatment.
In plain wordsIn healthy men, insulin resistance was apparent at 8 hr after HGH treatment.
Peptide
HGH (somatotropin)
Outcome
IncreaseInsulin resistance
Study
n: not reported in source
Outcome group
Glycemic control · Metabolic and weight
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
Insulin resistance was apparent at 8 hr posttreatment with HGH.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626206
07HumanNon-randomized trialMechanism
In healthy men, no differences in free fatty acid responses to insulin-induced hypoglycemia were observed in HGH-treated or saline-treated subjects.
In plain wordsIn healthy men, no differences in fatty acid responses to low blood sugar were observed in HGH-treated or saline-treated subjects.
Peptide
HGH (somatotropin)
Outcome
No significant changeFree fatty acid response to hypoglycemia
Study
n: not reported in source
Outcome group
Lipids · Metabolic and weight
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
No differences in FFA response after insulin-induced hypoglycemia were observed in GH-treated or saline-treated subjects.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626207
08HumanNon-randomized trialMechanism
In healthy men, cortisol responses to insulin-induced hypoglycemia were comparable after HGH and saline treatment.
In plain wordsIn healthy men, cortisol responses to low blood sugar were similar after HGH and saline treatment.
Peptide
HGH (somatotropin)
Outcome
No significant changeCortisol response to hypoglycemia
Study
n: not reported in source
Comparator
Saline-treated subjects
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
The rise in plasma cortisol after insulin-induced hypoglycemia was comparable in the GH-treated and saline-treated group.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626208
09HumanNon-randomized trialMechanism
In healthy men, cortisol diurnal variation persisted during GH suppression after HGH treatment.
In plain wordsIn healthy men, daily cortisol variation continued during growth hormone suppression after HGH treatment.
Peptide
HGH (somatotropin)
Outcome
No significant changeCortisol diurnal variation
Study
n: not reported in source
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
3 mg every 6 hr · 6 daysAs given in this study (human).
Source sentences
Summary
Diurnal variation in plasma cortisol was maintained during the period of GH suppression.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults.
Report a problemFND-0492626209

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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