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Study · Non-randomized trial · n = 2 · 1969

3 results

Studies of the pituitary-Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients.

Bardin CW, Ross GT, Rifkind AB, Cargille CM, Lipsett MB

The Journal of clinical investigation1 Nov 1969Cited by 89 (Europe PMC)

PMID4390462 (opens in a new tab)PMCIDPMC297457 (opens in a new tab)DOI10.1172/jci106170 (opens in a new tab)PepBankPUB-04390462
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    Prolonged HCG treatment failed to normalize plasma testosterone in two hyposmic patients.

    In plain wordsProlonged HCG treatment failed to restore normal blood testosterone in two hyposmic patients.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicableFailure to normalize testosterone
    Study

    n = 2

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Hyposmic patients whose plasma testosterone failed to normalize
    2 patients
    prolonged HCG treatment

    Source sentences

    Summary
    Prolonged treatment with HCG has failed to return plasma testosterone levels to normal in two hyposmic patients.
    2 context sentences
    Summary · context
    Pituitary and gonadal function was studied in seven chromatin-negative men, ages 15-27 yr, with retarded sexual and somatic development, skeletal anomalies, and hyposmia.
    Summary · context
    These hyposmic patients were compared with normal men, prepuberal boys and hypogonadal patients with hypopituitarism.
  2. 02HumanNon-randomized trialEfficacy outcome

    With HCG, testosterone increased less in hyposmic hypogonadal patients than in prepuberal subjects.

    In plain wordsWith HCG, testosterone rose less in hyposmic hypogonadal patients than in prepuberal subjects.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseTestosterone response versus prepuberal subjects
    Study

    n: not reported in source

    Comparator
    Prepuberal subjects receiving HCG
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The plasma testosterone levels were equally low in prepuberal, hypopituitary, and hyposmic patients but were increased to a greater extent by human chorionic gonadotropin (HCG) treatment in prepuberal and hypopituitary subjects than in the hyposmic patients.
    2 context sentences
    Summary · context
    Pituitary and gonadal function was studied in seven chromatin-negative men, ages 15-27 yr, with retarded sexual and somatic development, skeletal anomalies, and hyposmia.
    Summary · context
    These hyposmic patients were compared with normal men, prepuberal boys and hypogonadal patients with hypopituitarism.
  3. 03HumanNon-randomized trialEfficacy outcome

    With HCG, testosterone increased less in hyposmic hypogonadal patients than in hypopituitary subjects.

    In plain wordsWith HCG, testosterone rose less in hyposmic hypogonadal patients than in hypopituitary subjects.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseTestosterone response versus hypopituitary subjects
    Study

    n: not reported in source

    Comparator
    Hypopituitary subjects receiving HCG
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The plasma testosterone levels were equally low in prepuberal, hypopituitary, and hyposmic patients but were increased to a greater extent by human chorionic gonadotropin (HCG) treatment in prepuberal and hypopituitary subjects than in the hyposmic patients.
    2 context sentences
    Summary · context
    Pituitary and gonadal function was studied in seven chromatin-negative men, ages 15-27 yr, with retarded sexual and somatic development, skeletal anomalies, and hyposmia.
    Summary · context
    These hyposmic patients were compared with normal men, prepuberal boys and hypogonadal patients with hypopituitarism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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