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Study · Animal study (in vivo) · mouse · 1985

1 result

PLG and FMRFamide--endogenous peptides with marked inhibitory effects on opioid-induced feeding.

Kavaliers M, Hirst M

Progress in neuro-psychopharmacology & biological psychiatry1 Jan 1985Cited by 9 (Europe PMC)

PMID4089195 (opens in a new tab)DOI10.1016/0278-5846(85)90045-4 (opens in a new tab)PepBankPUB-04089195
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, PLG dose-dependently inhibited defeat-induced feeding.

    In plain wordsIn mice, PLG reduced feeding after social defeat in a dose-dependent manner.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseDefeat-induced feeding
    Study

    mousen: not reported in source

    Social defeat-induced feeding
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.01-10 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal administrations of prolyl-leucyl-glycinamide (PLG 0.01-10 mg/kg) leads to a dose-dependent inhibition of defeat-induced feeding that is analogous to that obtained after treatment with either the endogenous peptide FMRFamide (Phe-Met-Arg-Phe-NH2), or the prototypic opiate antagonist, naloxone.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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