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Study · Animal study (in vivo) · rat · 1985

3 results

[Modification of rat brain metabolism by long-term treatment with a peptide derivative].

Windisch M, Piswanger A

Arzneimittel-Forschung1 Jan 1985Cited by 1 (Europe PMC)

PMID4084338 (opens in a new tab)PepBankPUB-04084338
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, cerebrolysin treatment significantly decreased cerebral lactic acid levels.

    In plain wordsIn rats, cerebrolysin reduced lactic acid levels in the brain.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCerebral lactic acid concentration
    Study

    ratn: not reported in source

    Cerebrolysin-treated rats
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · 3, 5, 7 or 14 daysAs given in this study (rat).

    Source sentences

    Summary
    In all experiments treatment with the peptide derivative caused a significant decrease in cerebral lactic acid level and a gradual decrease in basal oxygen consumption of the brain homogenates correlated with duration of treatment.
    3 context sentences
    Summary · context
    These effects could be observed after two different peptide derivative dosages, in differently aged animals and were always manifest and significant between the 3rd and the 7th day of treatment.
    Summary · context
    Rats have been treated with a peptide derivative (Cerebrolysin) for 3, 5, 7 or 14 days.
    Summary · context
    Investigations were made on cerebral protein and lactic acid concentration and on in vitro oxygen consumption of brain homogenates derived from treated rats.
  2. 02LabIn vitro (cell-free)Activity measurement

    In brain homogenates from treated rats, basal oxygen consumption decreased progressively with cerebrolysin treatment duration.

    In plain wordsIn lab tests, brain homogenates from cerebrolysin-treated rats consumed less oxygen as treatment duration increased.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBasal oxygen consumption
    Study

    ratn: not reported in source

    Brain homogenates from treated rats
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · 3, 5, 7 or 14 daysAs given in this study (rat).

    Source sentences

    Summary
    In all experiments treatment with the peptide derivative caused a significant decrease in cerebral lactic acid level and a gradual decrease in basal oxygen consumption of the brain homogenates correlated with duration of treatment.
    3 context sentences
    Summary · context
    These effects could be observed after two different peptide derivative dosages, in differently aged animals and were always manifest and significant between the 3rd and the 7th day of treatment.
    Summary · context
    Rats have been treated with a peptide derivative (Cerebrolysin) for 3, 5, 7 or 14 days.
    Summary · context
    Investigations were made on cerebral protein and lactic acid concentration and on in vitro oxygen consumption of brain homogenates derived from treated rats.
  3. 03LabIn vitro (cell-free)Activity measurement

    In rat brain homogenates, higher-dose cerebrolysin pretreatment increased maximal respiratory activity after additional in vitro cerebrolysin application.

    In plain wordsIn lab tests, brain homogenates from rats given higher-dose cerebrolysin had increased maximal respiration after more cerebrolysin was applied.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMaximal respiratory activity after in vitro application
    Study

    ratn: not reported in source

    Brain homogenates from treated rats
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    2.5 ml/kg body weight/d · 3, 5, 7 or 14 daysAs given in this study (rat).

    Source sentences

    Summary
    The higher dosage of the peptide derivative (2.5 ml/kg body weight/d) caused a significant increase in maximal respiratory activity of brain homogenates after a further in vitro application of the derivative.
    2 context sentences
    Summary · context
    Rats have been treated with a peptide derivative (Cerebrolysin) for 3, 5, 7 or 14 days.
    Summary · context
    Investigations were made on cerebral protein and lactic acid concentration and on in vitro oxygen consumption of brain homogenates derived from treated rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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