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Study · Animal study (in vivo) · mouse · 1985

5 results

Thymosin alpha 1 exerts protective effect against the 5-FU induced bone marrow toxicity.

Ohta Y, Tezuka E, Tamura S, Yagi Y

International journal of immunopharmacology1 Jan 1985Cited by 15 (Europe PMC)

PMID4044100 (opens in a new tab)DOI10.1016/0192-0561(85)90163-8 (opens in a new tab)PepBankPUB-04044100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In BDF1 mice given 5-fluorouracil, thymosin alpha‑1 prevented the bone marrow toxicity as measured by bone marrow cellularity.

    In plain wordsIn mice given the drug 5-FU, thymosin alpha‑1 protected bone marrow cell numbers from the damage.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseBone marrow cellularity after 5-FU
    Study

    mousen: not reported in source

    5-fluorouracil-treated BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha 1 was shown to prevent the 5-fluorouracil(5-FU)-induced bone marrow toxicity in BDF1 mice, as determined by the cellularity
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In BDF1 mice given 5-fluorouracil, thymosin alpha‑1 prevented the bone marrow toxicity as measured by haemopoietic stem cells (CFU-s).

    In plain wordsIn mice given the drug 5-FU, thymosin alpha‑1 protected blood stem cell counts from the damage.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseHaemopoietic stem cells (CFU-s) after 5-FU
    Study

    mousen: not reported in source

    5-fluorouracil-treated BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha 1 was shown to prevent the 5-fluorouracil(5-FU)-induced bone marrow toxicity in BDF1 mice, as determined by the cellularity, haemopoietic stem cells (CFU-s) and granulocyte-macrophage colony forming unit (GM-CFU).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In BDF1 mice given 5-fluorouracil, thymosin alpha‑1 prevented the bone marrow toxicity as measured by GM-CFU.

    In plain wordsIn mice given the drug 5-FU, thymosin alpha‑1 protected bone marrow progenitor cell counts from the damage.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseGranulocyte-macrophage colony forming unit (GM-CFU) after 5-FU
    Study

    mousen: not reported in source

    5-fluorouracil-treated BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha 1 was shown to prevent the 5-fluorouracil(5-FU)-induced bone marrow toxicity in BDF1 mice, as determined by the cellularity, haemopoietic stem cells (CFU-s) and granulocyte-macrophage colony forming unit (GM-CFU).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In 5-fluorouracil-treated mice, thymosin alpha‑1 increased colony stimulating factor levels in sera and in culture media of spleen cells.

    In plain wordsIn mice given 5-FU, thymosin alpha‑1 raised colony stimulating factor levels in blood and in spleen cell cultures.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseColony stimulating factor levels in sera and spleen cell media
    Study

    mousen: not reported in source

    5-fluorouracil-treated BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, thymosin alpha 1 increased the levels of colony stimulating factor (CSF) in sera or in culture media of spleen cells derived from 5-FU-treated mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, thymosin alpha‑1 treatment prevented the loss of bone marrow cell capability to rescue lethally irradiated recipients that followed treatment with 5-FU and then anti-Thy 1,2 antibody.

    In plain wordsIn mice, thymosin alpha‑1 prevented damage to bone marrow cells caused by 5-FU followed by an anti-T-cell antibody.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseRescue capability of donor bone marrow cells after anti-Thy 1,2 antibody
    Study

    mousen: not reported in source

    5-fluorouracil-treated BDF1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The in vivo treatment of donor mice with anti-Thy 1,2 antibody following 5-FU abolished completely the capability of their bone marrow cells to save lethally irradiated recipients. Thymosin alpha 1 treatment prevented the damage by such combined treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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