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Study · Not a test of the peptide alone · 1985

3 results

The vasopressin and oxytocin neurons in the human supraoptic and paraventricular nucleus; changes with aging and in senile dementia.

Fliers E, Swaab DF, Pool CW, Verwer RW

Brain research1 Sept 1985Cited by 142 (Europe PMC)

PMID4041817 (opens in a new tab)DOI10.1016/0006-8993(85)91351-4 (opens in a new tab)PepBankPUB-04041817
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneObservational studyOther

    In human paraventricular and supraoptic nuclei, the mean profile area of oxytocin neurons did not change significantly with increasing age.

    In plain wordsIn people, oxytocin-producing cell size did not change with age.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin neuron profile area with age
    Study

    n: not reported in source

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    Mean profile area of OXT cells did not show any significant changes with increasing age.
    1 context sentence
    Summary · context
    In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the…

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneObservational studyOther

    In human paraventricular and supraoptic nuclei, the size of oxytocin cell nuclei did not change significantly with aging.

    In plain wordsIn people, the nuclei of oxytocin-producing cells did not change in size with age.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin neuron nuclear size with age
    Study

    n: not reported in source

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    Size of AVP and OXT cell nuclei did not change significantly with aging.
    1 context sentence
    Summary · context
    In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the…

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneObservational studyOther

    In human paraventricular and supraoptic nuclei, morphometric observations of oxytocin neurons in patients with senile dementia of the Alzheimer type were within the range for their age group.

    In plain wordsIn people with Alzheimer's-type dementia, observed oxytocin-neuron features were within the range for their age.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedOxytocin neuron morphology in senile dementia
    Study

    n: not reported in source

    paraventricular and supraoptic nuclei
    Comparator
    range for their age group
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    Observations in brains from patients with SDAT were within the range for their age group.
    1 context sentence
    Summary · context
    In order to investigate possible age-related changes in the human HNS, immunocytochemically identified AVP and OXT neurons in the paraventricular and supraoptic nucleus (PVN and SON) were analysed morphometrically in subjects from 10 to 93 years of age, including patients with senile dementia of the…

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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