Skip to content

Study · Animal study (in vivo) · rat · 1985

8 results

Tolerance and physical dependence induced by dermorphin in rats.

Broccardo M, Improta G, Negri L, Melchiorri P

European journal of pharmacology1 Mar 1985Cited by 12 (Europe PMC)

PMID4040026 (opens in a new tab)DOI10.1016/0014-2999(85)90028-7 (opens in a new tab)PepBankPUB-04040026
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats, tolerance assessed through shortened dermorphin analgesia developed dose-dependently within 48 h.

    In plain wordsIn rats, tolerance to dermorphin pain relief developed with dose dependence within 48 h.

    Peptide
    Dermorphin
    Outcome
    IncreaseAnalgesia tolerance
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    The development of tolerance, assessed by evaluating the time reduction of analgesia, catalepsy and rigidity, occurred in a dose-dependent fashion over a maximum period of 48 h.
    1 context sentence
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In rats, tolerance assessed through shortened dermorphin catalepsy developed dose-dependently within 48 h.

    In plain wordsIn rats, tolerance to dermorphin-induced catalepsy developed with dose dependence within 48 h.

    Peptide
    Dermorphin
    Outcome
    IncreaseCatalepsy tolerance
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    The development of tolerance, assessed by evaluating the time reduction of analgesia, catalepsy and rigidity, occurred in a dose-dependent fashion over a maximum period of 48 h.
    1 context sentence
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In rats, tolerance assessed through shortened dermorphin rigidity developed dose-dependently within 48 h.

    In plain wordsIn rats, tolerance to dermorphin-induced rigidity developed with dose dependence within 48 h.

    Peptide
    Dermorphin
    Outcome
    IncreaseRigidity tolerance
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    The development of tolerance, assessed by evaluating the time reduction of analgesia, catalepsy and rigidity, occurred in a dose-dependent fashion over a maximum period of 48 h.
    1 context sentence
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rats, dermorphin infusion established physical dependence after 3 days, demonstrated by naloxone-precipitated withdrawal.

    In plain wordsIn rats, dermorphin caused dependence after 3 days, demonstrated by withdrawal after naloxone.

    Peptide
    Dermorphin
    Outcome
    Not applicablePhysical dependence
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusion · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    After 3 days of peptide infusions into the rat brain, the dependent state was established and was revealed by precipitating the withdrawal syndrome with intraperitoneal naloxone injections.
    1 context sentence
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In dermorphin-dependent rats, naloxone-precipitated withdrawal included escape behavior, qualitatively similar to morphine dependence.

    In plain wordsIn rats dependent on dermorphin, withdrawal included escape behavior similar to morphine withdrawal.

    Peptide
    Dermorphin
    Outcome
    Not applicableWithdrawal escape behavior
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    Escape behavior, shaking, salivation and rhynorrhea were the main symptoms, qualitatively similar to those obtained in rats made dependent on morphine.
    2 context sentences
    Summary · context
    After 3 days of peptide infusions into the rat brain, the dependent state was established and was revealed by precipitating the withdrawal syndrome with intraperitoneal naloxone injections.
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In dermorphin-dependent rats, naloxone-precipitated withdrawal included shaking, qualitatively similar to morphine dependence.

    In plain wordsIn rats dependent on dermorphin, withdrawal included shaking similar to morphine withdrawal.

    Peptide
    Dermorphin
    Outcome
    Not applicableWithdrawal shaking
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    Escape behavior, shaking, salivation and rhynorrhea were the main symptoms, qualitatively similar to those obtained in rats made dependent on morphine.
    2 context sentences
    Summary · context
    After 3 days of peptide infusions into the rat brain, the dependent state was established and was revealed by precipitating the withdrawal syndrome with intraperitoneal naloxone injections.
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In dermorphin-dependent rats, naloxone-precipitated withdrawal included salivation, qualitatively similar to morphine dependence.

    In plain wordsIn rats dependent on dermorphin, withdrawal included salivation similar to morphine withdrawal.

    Peptide
    Dermorphin
    Outcome
    Not applicableWithdrawal salivation
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    Escape behavior, shaking, salivation and rhynorrhea were the main symptoms, qualitatively similar to those obtained in rats made dependent on morphine.
    2 context sentences
    Summary · context
    After 3 days of peptide infusions into the rat brain, the dependent state was established and was revealed by precipitating the withdrawal syndrome with intraperitoneal naloxone injections.
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.
  8. 08AnimalAnimal study (in vivo)Safety outcome

    In dermorphin-dependent rats, naloxone-precipitated withdrawal included rhynorrhea, qualitatively similar to morphine dependence.

    In plain wordsIn rats dependent on dermorphin, withdrawal included nasal discharge similar to morphine withdrawal.

    Peptide
    Dermorphin
    Outcome
    Not applicableWithdrawal rhynorrhea
    Study

    ratn: not reported in source

    chronic intracerebroventricular dermorphin infusion
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    Escape behavior, shaking, salivation and rhynorrhea were the main symptoms, qualitatively similar to those obtained in rats made dependent on morphine.
    2 context sentences
    Summary · context
    After 3 days of peptide infusions into the rat brain, the dependent state was established and was revealed by precipitating the withdrawal syndrome with intraperitoneal naloxone injections.
    Summary · context
    Rats chronically implanted with osmotic minipumps in the left lateral ventricle were used to study the ability of dermorphin to produce tolerance and physical dependence.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.