Variables determining the growth hormone response of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in the rat.

Sartor O, Bowers CY, Reynolds GA, Momany FA

Endocrinology1 Oct 1985Cited by 33 (Europe PMC)

PMID4029086DOI10.1210/endo-117-4-1441PepBankPUB-04029086

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, GH-RP-6 produced much larger GH responses before 15 days of age than at 21 days or older.
In plain wordsIn rats, GH-RP-6 produced larger hormone responses in younger animals than in older animals.
Peptide
GHRP-6
Outcome
IncreaseAge-dependent GH response
Study
ratn: not reported in source
rats
Comparator
rats 21 days and older
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
Animals less than 15 days of age had much larger responses than did rats 21 days and older.
2 context sentences(design, population, supporting numbers)
Summary · context
The magnitude of the GH response to sc GH-RP-6 was dependent on the age and sex of the rat.
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats aged 10 days, males had larger GH responses to GH-RP-6 than females.
In plain wordsIn rats aged 10 days, GH-RP-6 produced larger growth hormone responses in males than females.
Peptide
GHRP-6
Outcome
IncreaseSex-dependent GH response at 10 days
Study
ratn: not reported in source
rats
Comparator
female rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 10 days of age the male rat had a larger GH response than the female.
2 context sentences(design, population, supporting numbers)
Summary · context
The magnitude of the GH response to sc GH-RP-6 was dependent on the age and sex of the rat.
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908602
03AnimalAnimal study (in vivo)Efficacy outcome
In Fla-63-pretreated rats aged 21 days, females had larger GH-RP-6 responses than males.
In plain wordsIn rats aged 21 days after Fla-63 pretreatment, GH-RP-6 produced larger hormone responses in females than males.
Peptide
GHRP-6
Outcome
IncreaseSex-dependent GH response with Fla-63 at 21 days
Study
ratn: not reported in source
rats
Comparator
Fla-63-pretreated males
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 21 days of age, bis(4-methyl 1-homo-piperazinyl-thiocarbonyl) disulfide (Fla-63)-pretreated females had larger responses than did Fla-63-pretreated males.
2 context sentences(design, population, supporting numbers)
Summary · context
The magnitude of the GH response to sc GH-RP-6 was dependent on the age and sex of the rat.
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908603
04AnimalAnimal study (in vivo)Efficacy outcome
In Fla-63-pretreated adult female rats, GH-RP-6 stimulated GH release.
In plain wordsIn adult female rats after Fla-63 pretreatment, GH-RP-6 stimulated growth hormone release.
Peptide
GHRP-6
Outcome
IncreaseAdult female GH release with Fla-63
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
In the Fla-63-pretreated adult rat, sc GH-RP-6 stimulated GH release in the female but not in the male.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908604
05AnimalAnimal study (in vivo)Efficacy outcome
In Fla-63-pretreated adult male rats, GH-RP-6 did not stimulate GH release.
In plain wordsIn adult male rats after Fla-63 pretreatment, GH-RP-6 did not stimulate growth hormone release.
Peptide
GHRP-6
Outcome
No significant changeAdult male GH release with Fla-63
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
In the Fla-63-pretreated adult rat, sc GH-RP-6 stimulated GH release in the female but not in the male.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908605
06AnimalAnimal study (in vivo)Activity measurement
In male rats aged 10 days, subcutaneous GH-RP-6 had an ED50 of 0.4 micrograms.
In plain wordsIn male rats aged 10 days, the half-maximal effective dose of GH-RP-6 was 0.4 micrograms.
Peptide
GHRP-6
Outcome
Not applicableED50 in neonatal males
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Measurements
ED50
0.4 micrograms
10-day-old male
Source sentences
Summary
In the 10-day-old male, the ED50 for sc GH-RP-6 was 0.4 micrograms, and the maximal serum GH response was 800 ng/ml.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908606
07AnimalAnimal study (in vivo)Efficacy outcome
In male rats aged 10 days, subcutaneous GH-RP-6 produced a maximal serum GH response of 800 ng/ml.
In plain wordsIn male rats aged 10 days, the maximum blood growth hormone response to GH-RP-6 was 800 ng/ml.
Peptide
GHRP-6
Outcome
IncreaseMaximal GH response in neonatal males
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Measurements
Maximal serum GH
800 ng/ml
10-day-old male
Source sentences
Summary
In the 10-day-old male, the ED50 for sc GH-RP-6 was 0.4 micrograms, and the maximal serum GH response was 800 ng/ml.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908607
08AnimalAnimal study (in vivo)Activity measurement
In Fla-63-pretreated female rats aged 21 days, subcutaneous GH-RP-6 had an ED50 of 3.0 micrograms.
In plain wordsIn female rats aged 21 days after Fla-63 pretreatment, the half-maximal GH-RP-6 dose was 3.0 micrograms.
Peptide
GHRP-6
Outcome
Not applicableED50 in Fla-63-pretreated females
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Measurements
ED50
3 micrograms
21-day-old female, Fla-63 pretreatment
Source sentences
Summary
In the 21-day-old female Fla-63-pretreated rat, the ED50 for sc GH-RP-6 was 3.0 micrograms, and the maximal GH response was 200 ng/ml.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908608
09AnimalAnimal study (in vivo)Efficacy outcome
In Fla-63-pretreated female rats aged 21 days, subcutaneous GH-RP-6 produced a maximal GH response of 200 ng/ml.
In plain wordsIn female rats aged 21 days after Fla-63 pretreatment, the maximum GH-RP-6 hormone response was 200 ng/ml.
Peptide
GHRP-6
Outcome
IncreaseMaximal GH response in Fla-63-pretreated females
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Measurements
Maximal GH response
200 ng/ml
21-day-old female, Fla-63 pretreatment
Source sentences
Summary
In the 21-day-old female Fla-63-pretreated rat, the ED50 for sc GH-RP-6 was 3.0 micrograms, and the maximal GH response was 200 ng/ml.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908609
10AnimalAnimal study (in vivo)Activity measurement
In pentobarbital-anesthetized female rats aged 21 days, intravenous GH-RP-6 had an ED50 of 0.5 micrograms.
In plain wordsIn anesthetized female rats aged 21 days, the half-maximal intravenous GH-RP-6 dose was 0.5 micrograms.
Peptide
GHRP-6
Outcome
Not applicableED50 in anesthetized females
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Measurements
ED50
0.5 micrograms
21-day-old female, pentobarbital anesthesia
Source sentences
Summary
In the 21-day-old female pentobarbital-anesthetized rat, iv GH-RP-6 had an ED50 of 0.5 micrograms and a maximal serum GH response of 2500 ng/ml.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908610
11AnimalAnimal study (in vivo)Efficacy outcome
In pentobarbital-anesthetized female rats aged 21 days, intravenous GH-RP-6 produced a maximal serum GH response of 2500 ng/ml.
In plain wordsIn anesthetized female rats aged 21 days, the maximum blood growth hormone response to intravenous GH-RP-6 was 2500 ng/ml.
Peptide
GHRP-6
Outcome
IncreaseMaximal GH response in anesthetized females
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Measurements
Maximal serum GH
2500 ng/ml
21-day-old female, pentobarbital anesthesia
Source sentences
Summary
In the 21-day-old female pentobarbital-anesthetized rat, iv GH-RP-6 had an ED50 of 0.5 micrograms and a maximal serum GH response of 2500 ng/ml.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908611
12AnimalAnimal study (in vivo)Efficacy outcome
In rats, a single subcutaneous GH-RP-6 injection reduced subsequent GH-RP-6 responses in a dose- and time-dependent manner.
In plain wordsIn rats, one GH-RP-6 injection reduced later responses to GH-RP-6 according to dose and time.
Peptide
GHRP-6
Outcome
DecreaseSubsequent GH-RP-6 response after single injection
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
A marked dose- and time-dependent decrease of subsequent GH-RP-6 responses occurred after a single sc GH-RP-6 injection.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908612
13AnimalAnimal study (in vivo)Efficacy outcome
In rats, GH-RP-6 pretreatment did not change the GH response to MRZ 2549.
In plain wordsIn rats, prior GH-RP-6 exposure did not change the growth hormone response to MRZ 2549.
Peptide
GHRP-6
Outcome
No significant changeMRZ 2549 GH response after GH-RP-6
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Decreases in pituitary GH or increases in somatostatin secretion would not explain this decreased response because the GH response of MRZ 2549, an opiate agonist, was unchanged by GH-RP-6 pretreatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908613
14AnimalAnimal study (in vivo)Efficacy outcome
In rats, chronic daily GH-RP-6 injections enhanced the response to GH-RP-6.
In plain wordsIn rats, repeated daily GH-RP-6 injections strengthened the growth hormone response to GH-RP-6.
Peptide
GHRP-6
Outcome
IncreaseGH-RP-6 response after chronic injections
Study
ratn: not reported in source
rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · subcutaneous · chronic daily injectionsAs given in this study (rat).
Source sentences
Summary
In contrast to the acute effect of GH-RP-6, chronic daily injections of GH-RP-6 resulted in an enhancement of the GH-RP-6 response.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study the variables determining the in vivo responses were examined in the rat.
Report a problemFND-0402908614

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.