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Study · Non-randomized trial · n = 3 · 1985

3 results

Plasma oxytocin concentrations in man after different routes of administration of synthetic oxytocin.

Landgraf R

Experimental and clinical endocrinology1 Apr 1985Cited by 39 (Europe PMC)

PMID4018162 (opens in a new tab)DOI10.1055/s-0029-1210444 (opens in a new tab)PepBankPUB-04018162
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In three men, nasal spray of synthetic oxytocin raised plasma oxytocin markedly above basal levels.

    In plain wordsIn three men, oxytocin nasal spray raised oxytocin levels in blood well above the starting level.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after nasal spray
    Study

    n = 3

    Comparator
    Basal plasma oxytocin
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    65-100 micrograms total · nasal sprayAs given in this study (human).

    Measurements

    Plasma oxytocin
    36 to 85 pg/ml
    nasal spray
    Basal plasma oxytocin
    < 10 pg/ml
    basal

    Source sentences

    Summary
    As compared to basal levels (below 10 pg/ml), plasma oxytocin was found to be elevated markedly (36 to 85 pg/ml) in response to application by nasal spray (total dose: 65 to 100 micrograms).
    1 context sentence
    Summary · context
    Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin.
  2. 02HumanNon-randomized trialPharmacokinetics

    In three men, intramuscular synthetic oxytocin produced very high plasma oxytocin levels.

    In plain wordsIn three men, oxytocin injected into muscle gave very high oxytocin levels in blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after intramuscular injection
    Study

    n = 3

    Comparator
    Basal plasma oxytocin
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    25 micrograms · intramuscularAs given in this study (human).

    Measurements

    Plasma oxytocin
    360 to 480 pg/ml
    intramuscular

    Source sentences

    Summary
    Intramuscular injection (25 micrograms) resulted in very high oxytocin levels (360 to 480 pg/ml)
    1 context sentence
    Summary · context
    Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin.
  3. 03HumanNon-randomized trialPharmacokinetics

    In three men, buccal synthetic oxytocin did not raise plasma oxytocin above basal levels.

    In plain wordsIn three men, oxytocin taken in the cheek did not raise oxytocin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin after buccal administration
    Study

    n = 3

    Comparator
    Basal plasma oxytocin
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    70 micrograms · buccalAs given in this study (human).

    Measurements

    Plasma oxytocin
    < 10 pg/ml
    buccal

    Source sentences

    Summary
    whereas buccal administration (70 micrograms) was proved to be ineffective (levels below 10 pg/ml plasma).
    1 context sentence
    Summary · context
    Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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