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Study · Animal study (in vivo) · rat · 1985

4 results

Development of tolerance to the effect of dermorphin on gastric emptying in the rat.

Broccardo M

Pharmacological research communications1 Apr 1985Cited by 5 (Europe PMC)

PMID4011652 (opens in a new tab)DOI10.1016/0031-6989(85)90014-1 (opens in a new tab)PepBankPUB-04011652
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular or subcutaneous dermorphin delayed gastric emptying.

    In plain wordsIn rats, dermorphin delayed stomach emptying.

    Peptide
    Dermorphin
    Outcome
    IncreaseGastric emptying delay
    Study

    ratn: not reported in source

    gastric emptying
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricular or subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin produced a delay in G.E. when it was injected i.c.v. or s.c.,
    1 context sentence
    Summary · context
    The development of tolerance to the effect of dermorphin on gastric emptying (G.E.) induced by repeated subcutaneous (s.c.), intracerebroventricular (i.c.v.) injections or by i.c.v. infusion of this peptide, was studied in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, acute intracerebroventricular dermorphin no longer significantly delayed gastric emptying after repeated treatment.

    In plain wordsIn rats, repeated dermorphin treatment removed the significant stomach-emptying delay from an acute brain injection.

    Peptide
    Dermorphin
    Outcome
    No significant changeTolerance to intracerebroventricular gastric effect
    Study

    ratn: not reported in source

    gastric emptying
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricular · 5 days, twice dailyAs given in this study (rat).

    Source sentences

    Summary
    but when for 5 days rats were injected twice daily with the same dose of peptide, the acute i.c.v. injection of dermorphin no longer produced a significant delay in G.E. demonstrating an establishment of tolerance to this effect.
    1 context sentence
    Summary · context
    The development of tolerance to the effect of dermorphin on gastric emptying (G.E.) induced by repeated subcutaneous (s.c.), intracerebroventricular (i.c.v.) injections or by i.c.v. infusion of this peptide, was studied in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, tolerance to subcutaneous dermorphin required 10 days.

    In plain wordsIn rats, tolerance to dermorphin injections under the skin required 10 days.

    Peptide
    Dermorphin
    Outcome
    Not applicableTolerance to subcutaneous gastric effect
    Study

    ratn: not reported in source

    gastric emptying
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneous · 10 daysAs given in this study (rat).

    Measurements

    Time to tolerance
    10 days
    subcutaneous injection

    Source sentences

    Summary
    However, 10 days were necessary to establish tolerance to s.c. injection of the peptide.
    1 context sentence
    Summary · context
    The development of tolerance to the effect of dermorphin on gastric emptying (G.E.) induced by repeated subcutaneous (s.c.), intracerebroventricular (i.c.v.) injections or by i.c.v. infusion of this peptide, was studied in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, tolerance to dermorphin-induced gastric delay varied inversely with infusion time and developed in 2 days.

    In plain wordsIn rats, tolerance to dermorphin's stomach-emptying effect varied inversely with infusion time and developed in 2 days.

    Peptide
    Dermorphin
    Outcome
    Not applicableTolerance during intracerebroventricular infusion
    Study

    ratn: not reported in source

    gastric emptying
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated · intracerebroventricular infusionAs given in this study (rat).

    Measurements

    Time to tolerance
    2 days
    intracerebroventricular infusion

    Source sentences

    Summary
    When dermorphin was i.c.v. infused by a minipump, tolerance to delay of G.E. was inversely proportional to infusion time and it took 2 days to establish tolerance to this peripheral effect.
    1 context sentence
    Summary · context
    The development of tolerance to the effect of dermorphin on gastric emptying (G.E.) induced by repeated subcutaneous (s.c.), intracerebroventricular (i.c.v.) injections or by i.c.v. infusion of this peptide, was studied in rats.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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