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Study · Animal study (in vivo) · mouse · 1985

4 results

Thymosin fraction 5 causes increased serum corticosterone in rodents in vivo.

McGillis JP, Hall NR, Vahouny GV, Goldstein AL

Journal of immunology (Baltimore, Md. : 1950)1 Jun 1985Cited by 25 (Europe PMC)

PMID3989302 (opens in a new tab)DOI10.4049/jimmunol.134.6.3952 (opens in a new tab)PepBankPUB-03989302
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intraperitoneal thymosin alpha‑1 at doses up to 100 micrograms did not change serum corticosterone.

    In plain wordsIn mice, thymosin alpha‑1 did not change blood corticosterone at doses up to 100 micrograms.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSerum corticosterone after thymosin alpha 1 in mice
    Study

    mousen: not reported in source

    mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    up to 100 micrograms · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    There was no effect on serum corticosterone in mice when Thymosin alpha 1 (a 28 amino acid peptide isolated from TF5) was injected i.p. at doses up to 100 micrograms.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 02AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In male Swiss Webster mice, intraperitoneal thymosin fraction 5 caused a dose-dependent increase in serum corticosterone.

    In plain wordsIn mice, an extract called thymosin fraction 5 raised blood corticosterone in a dose-dependent way.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum corticosterone after thymosin fraction 5 in mice
    Study

    mousen: not reported in source

    male Swiss Webster mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In these studies it was found that i.p. injection of thymosin fraction 5 (TF5) caused a dose-dependent increase in serum corticosterone in male Swiss Webster mice and in male Wistar rats.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 03AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    In male Wistar rats, intraperitoneal thymosin fraction 5 caused a dose-dependent increase in serum corticosterone.

    In plain wordsIn rats, an extract called thymosin fraction 5 raised blood corticosterone in a dose-dependent way.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSerum corticosterone after thymosin fraction 5 in rats
    Study

    ratn: not reported in source

    male Wistar rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    In these studies it was found that i.p. injection of thymosin fraction 5 (TF5) caused a dose-dependent increase in serum corticosterone in male Swiss Webster mice and in male Wistar rats.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 04AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome

    Thymosin fraction 5 raised corticosterone only when basal serum levels were low (below 80 ng/ml) and had no or minimal effect when baseline levels were above 80 ng/ml.

    In plain wordsIn rodents, the thymosin fraction 5 extract raised corticosterone only when starting levels were low.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedDependence of thymosin fraction 5 steroidogenic effect on basal corticosterone
    Study

    mouse, ratn: not reported in source

    rodents
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    basal corticosterone threshold
    < 80 ng/ml
    steroidogenic effect seen

    Source sentences

    Summary
    The steroidogenic effects of TF5 were seen only when the basal levels of serum corticosterone were low (less than 80 ng/ml). In studies in which the baseline levels in the animal colony were elevated (greater than 80 ng/ml), there were no steroidogenic effects, or they were minimal.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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