Differential effects of naloxone on the release of neurohypophysial hormones in normotensive and spontaneously hypertensive rats.

Rosella-Dampman LM, Emmert SE, Keil LC, Summy-Long JY

Brain research1 Jan 1985Cited by 7 (Europe PMC)

PMID3978414DOI10.1016/0006-8993(85)90317-8PepBankPUB-03978414

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
Pituitary oxytocin content was reduced in spontaneously hypertensive rats compared with normotensive controls.
In plain wordsIn rats, the body's own oxytocin stored in the pituitary was lower in hypertensive rats than in normal rats.
Peptide
Oxytocin
Outcome
DecreasePituitary oxytocin content in SHR
Study
ratn: not reported in source
spontaneously hypertensive rats (SHR) and normotensive controls (WKY, Sprague-Dawley)
Comparator
Normotensive control rats
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
The pituitary content, plasma concentration, and urinary excretion of OT were reduced (P less than 0.05) in SHRs
2 context sentences(design, population, supporting numbers)
Summary · context
Concentrations of the neurohypophysial hormones in plasma and the pituitary were measured in 17-week-old SHRs and two strains of normotensive controls.
Summary · context
Animals were decapitated 20 min after s.c. injection of saline (1 ml/kg) or naloxone hydrochloride (1 or 10 mg/kg).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0397841401
02AnimalEndogenous levelAnimal study (in vivo)Other
Plasma oxytocin concentration was reduced in spontaneously hypertensive rats compared with normotensive controls.
In plain wordsIn rats, the body's own oxytocin level in blood was lower in hypertensive rats than in normal rats.
Peptide
Oxytocin
Outcome
DecreasePlasma oxytocin concentration in SHR
Study
ratn: not reported in source
spontaneously hypertensive rats (SHR) and normotensive controls (WKY, Sprague-Dawley)
Comparator
Normotensive control rats
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
The pituitary content, plasma concentration, and urinary excretion of OT were reduced (P less than 0.05) in SHRs
2 context sentences(design, population, supporting numbers)
Summary · context
Concentrations of the neurohypophysial hormones in plasma and the pituitary were measured in 17-week-old SHRs and two strains of normotensive controls.
Summary · context
Animals were decapitated 20 min after s.c. injection of saline (1 ml/kg) or naloxone hydrochloride (1 or 10 mg/kg).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0397841402
03AnimalEndogenous levelAnimal study (in vivo)Other
Urinary oxytocin excretion was reduced in spontaneously hypertensive rats compared with normotensive controls.
In plain wordsIn rats, the body's own oxytocin passed in urine was lower in hypertensive rats than in normal rats.
Peptide
Oxytocin
Outcome
DecreaseUrinary oxytocin excretion in SHR
Study
ratn: not reported in source
spontaneously hypertensive rats (SHR) and normotensive controls (WKY, Sprague-Dawley)
Comparator
Normotensive control rats
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
The pituitary content, plasma concentration, and urinary excretion of OT were reduced (P less than 0.05) in SHRs
3 context sentences(design, population, supporting numbers)
Summary · context
In addition, neurohypophysial hormones excreted during the day (08.00-17.30 h) and night (17.30-08.00 h) were determined in urine from 16-week-old animals kept in metabolic cages for 5 days.
Summary · context
Concentrations of the neurohypophysial hormones in plasma and the pituitary were measured in 17-week-old SHRs and two strains of normotensive controls.
Summary · context
Animals were decapitated 20 min after s.c. injection of saline (1 ml/kg) or naloxone hydrochloride (1 or 10 mg/kg).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0397841403
04AnimalEndogenous levelAnimal study (in vivo)Other
Naloxone raised the plasma oxytocin concentration in Wistar Kyoto rats.
In plain wordsIn rats, the drug naloxone raised the body's own oxytocin level in blood in one normal rat strain.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin after naloxone in WKY rats
Study
ratn: not reported in source
spontaneously hypertensive rats (SHR) and normotensive controls (WKY, Sprague-Dawley)
Comparator
Saline
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Naloxone elevated (P less than 0.05) the plasma concentration of OT in WKY animals
2 context sentences(design, population, supporting numbers)
Summary · context
Concentrations of the neurohypophysial hormones in plasma and the pituitary were measured in 17-week-old SHRs and two strains of normotensive controls.
Summary · context
Animals were decapitated 20 min after s.c. injection of saline (1 ml/kg) or naloxone hydrochloride (1 or 10 mg/kg).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0397841404
05AnimalEndogenous levelAnimal study (in vivo)Other
Naloxone did not change plasma oxytocin in Sprague-Dawley rats.
In plain wordsIn rats, naloxone did not change the body's own oxytocin level in blood in the Sprague-Dawley strain.
Peptide
Oxytocin
Outcome
No significant changePlasma oxytocin after naloxone in Sprague-Dawley rats
Study
ratn: not reported in source
spontaneously hypertensive rats (SHR) and normotensive controls (WKY, Sprague-Dawley)
Comparator
Saline
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Neither [VP] nor [OT] in plasma was changed by naloxone in Sprague-Dawley rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Concentrations of the neurohypophysial hormones in plasma and the pituitary were measured in 17-week-old SHRs and two strains of normotensive controls.
Summary · context
Animals were decapitated 20 min after s.c. injection of saline (1 ml/kg) or naloxone hydrochloride (1 or 10 mg/kg).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0397841405
06AnimalEndogenous levelAnimal study (in vivo)Other
Naloxone did not alter pituitary oxytocin stores in hypertensive or normotensive rats.
In plain wordsIn rats, naloxone did not change the body's own oxytocin stored in the pituitary.
Peptide
Oxytocin
Outcome
No significant changePituitary oxytocin stores after naloxone
Study
ratn: not reported in source
spontaneously hypertensive rats (SHR) and normotensive controls (WKY, Sprague-Dawley)
Comparator
Saline
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Pituitary stores of the neurohypophysial hormones were not altered by naloxone in either hypertensive or normotensive rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Concentrations of the neurohypophysial hormones in plasma and the pituitary were measured in 17-week-old SHRs and two strains of normotensive controls.
Summary · context
Animals were decapitated 20 min after s.c. injection of saline (1 ml/kg) or naloxone hydrochloride (1 or 10 mg/kg).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0397841406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:54 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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