Central release of oxytocin, vasopressin and neurophysin by magnocellular neurone depolarization: evidence in slices of guinea pig and rat hypothalamus.

Mason WT, Hatton GI, Ho YW, Chapman C, Robinson IC

Neuroendocrinology1 Jan 1986Cited by 62 (Europe PMC)

PMID3960274DOI10.1159/000124457PepBankPUB-03960274

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueOther
In rat hypothalamic slices, depolarization of the supraoptic or paraventricular nucleus with high K+ solutions released oxytocin into areas close to the nucleus.
In plain wordsIn rat brain slices, the body's own oxytocin was released inside the hypothalamus when neurons were activated.
Peptide
Oxytocin
Outcome
IncreaseLocal oxytocin release after depolarization
Study
ratn: not reported in source
Rat hypothalamic slices
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Using slices of rat hypothalamus maintained in vitro, we have examined release of oxytocin and vasopressin under conditions of increased neuronal activity. We report here that when the supraoptic or paraventricular nucleus is depolarized with high K+ solutions, hormone is released into areas close to the nucleus.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0396027401
02LabEndogenous levelEx vivo tissueOther
In guinea pig hypothalamic slices, neurophysin may be co-released with oxytocin and vasopressin.
In plain wordsIn guinea pig brain slices, a related protein may be released together with the body's own oxytocin.
Peptide
Oxytocin
Outcome
Not applicableNeurophysin co-release with oxytocin
Study
guinea pign: not reported in source
Guinea pig hypothalamic slices
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Similar experiments with guinea pig hypothalamus suggest that neurophysin may also be co-released with oxytocin and vasopressin.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0396027402
03LabEndogenous levelEx vivo tissueOther
In hypothalamic slices, acetylcholine evoked a rise in local release of vasopressin but not of oxytocin.
In plain wordsIn brain slices, acetylcholine raised local vasopressin release but did not raise the body's own oxytocin release.
Peptide
Oxytocin
Outcome
No significant changeLocal oxytocin release after acetylcholine
Study
n: not reported in source
Hypothalamic slices
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Use of acetylcholine to selectively stimulate vasopressin neurones appears to evoke a rise in local release of vasopressin but not oxytocin.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0396027403

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Version history

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Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

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