In Long-Evans and Brattleboro rats, acute salt loading raised plasma oxytocin-associated neurophysin in step with plasma osmolality, with a similar slope in both strains over the first 40 min.
In plain wordsIn rats, a salt load raised a blood marker of the body's own oxytocin release, with a similar rise in both rat types.
- Peptide
- Oxytocin
- Outcome
- IncreasePlasma oxytocin-associated neurophysin rise with osmolality, first 40 min
- Study
ratn: not reported in source
Long-Evans and Brattleboro homozygous rats- Outcome group
- Endogenous peptide levels · Endocrine and hormones
Measurements
- Slope of change in [OT-RNP] against change in Posm
- 21.6 fmol ml-1 mosm-1 kg-1
- Long-Evans rats
- Slope of change in [OT-RNP] against change in Posm
- 19.7 fmol ml-1 mosm-1 kg-1
- Brattleboro (DI) rats
Source sentences
An increase in Posm was associated with a rise in [OT-RNP] and the relationship between delta [OT-RNP] and delta Posm was similar for both LE and DI rats over the first 40 min of infusion (21.6 and 19.7 fmol ml-1 mosm-1 kg-1, respectively).
2 context sentences(design, population, supporting numbers)
Plasma oxytocin-associated neurophysin concentration [( OT-RNP]) was used to evaluate the responsiveness of oxytocinergic neurons to an acute salt load in Long-Evans (LE) rats and Brattleboro homozygous (DI) rats.
Acute salt loading was induced by infusing 18% saline for 60 min into conscious, trained, chronically catheterized animals and plasma osmolality (Posm) and mean arterial pressure (MAP) were monitored.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.