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Study · Animal study (in vivo) · 1985

6 results

Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.

Rogers RC, Hermann GE

Peptides1 Nov 1985Cited by 86 (Europe PMC)

PMID3938842 (opens in a new tab)DOI10.1016/0196-9781(85)90441-3 (opens in a new tab)PepBankPUB-03938842
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    Oxytocin injected at the dorsal motor nucleus of the vagus substantially increased gastric acid secretion.

    In plain wordsIn animals, oxytocin injected into a brainstem area raised stomach acid secretion.

    Peptide
    Oxytocin
    Outcome
    IncreaseGastric acid secretion after dorsal motor nucleus oxytocin injection
    Study

    n: not reported in source

    dorsal motor nucleus of the vagus
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    11 picomoles · injection centered on the dorsal motor nucleus of the vagusAs given in this study.

    Measurements

    dose
    11 picomoles
    oxytocin

    Source sentences

    Summary
    Injections of oxytocin and TRH (11 picomoles), centered on the dorsal motor nucleus of the vagus, substantially increased gastric acid secretion.
    1 context sentence
    Title · context
    Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    Oxytocin injected at the dorsal motor nucleus of the vagus consistently reduced heart rate.

    In plain wordsIn animals, oxytocin injected into a brainstem area lowered heart rate.

    Peptide
    Oxytocin
    Outcome
    DecreaseHeart rate after dorsal motor nucleus oxytocin injection
    Study

    n: not reported in source

    dorsal motor nucleus of the vagus
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    11 picomoles · injection centered on the dorsal motor nucleus of the vagusAs given in this study.

    Source sentences

    Summary
    Additionally, oxytocin, but not TRH, simultaneously produced a consistent reduction in heart rate.
    1 context sentence
    Title · context
    Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    Oxytocin applied to the area postrema gave no consistent effect on gastric secretion.

    In plain wordsIn animals, oxytocin applied to a different brainstem area had no consistent effect on stomach acid.

    Peptide
    Oxytocin
    Outcome
    No significant changeGastric secretion after area postrema oxytocin
    Study

    n: not reported in source

    dorsal motor nucleus of the vagus
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    22 picomoles · application to the area postremaAs given in this study.

    Source sentences

    Summary
    Application of oxytocin or TRH to the area postrema, at double the dosage (22 picomoles) yielded no consistent effects on either gastric secretion or heart rate.
    1 context sentence
    Title · context
    Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    Oxytocin applied to the area postrema gave no consistent effect on heart rate.

    In plain wordsIn animals, oxytocin applied to a different brainstem area had no consistent effect on heart rate.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate after area postrema oxytocin
    Study

    n: not reported in source

    dorsal motor nucleus of the vagus
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    22 picomoles · application to the area postremaAs given in this study.

    Source sentences

    Summary
    Application of oxytocin or TRH to the area postrema, at double the dosage (22 picomoles) yielded no consistent effects on either gastric secretion or heart rate.
    1 context sentence
    Title · context
    Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    The oxytocin antagonist ETOV or atropine eliminated the gastric acid response to dorsal motor nucleus oxytocin.

    In plain wordsIn animals, an oxytocin blocker or atropine stopped oxytocin from raising stomach acid.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced gastric effect with oxytocin antagonist or atropine
    Study

    n: not reported in source

    dorsal motor nucleus of the vagus
    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    Both the gastric and cardiac effects of oxytocin were eliminated by the central injections of oxytocin antagonist dEt2Tyr(Et)Orn8Vasotocin (ETOV; 6 picomoles) or peripheral administration of atropine (300 micrograms/kg, IP).
    1 context sentence
    Title · context
    Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    The oxytocin antagonist ETOV or atropine eliminated the heart rate response to dorsal motor nucleus oxytocin.

    In plain wordsIn animals, an oxytocin blocker or atropine stopped oxytocin from lowering heart rate.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced heart rate effect with oxytocin antagonist or atropine
    Study

    n: not reported in source

    dorsal motor nucleus of the vagus
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Both the gastric and cardiac effects of oxytocin were eliminated by the central injections of oxytocin antagonist dEt2Tyr(Et)Orn8Vasotocin (ETOV; 6 picomoles) or peripheral administration of atropine (300 micrograms/kg, IP).
    1 context sentence
    Title · context
    Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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