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Study · Not a test of the peptide alone · 1985

3 results

The aluminum-induced increase in blood-brain barrier permeability to delta-sleep-inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels.

Banks WA, Kastin AJ

Psychopharmacology1 Jan 1985Cited by 18 (Europe PMC)

PMID3927370 (opens in a new tab)DOI10.1007/bf00431689 (opens in a new tab)PepBankPUB-03927370
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other

    In adult rats, aluminum 100 mg/kg raised blood-brain barrier permeability to intracarotid 125I-N-Tyr-DSIP, with whole-brain radioactivity 45% higher than in controls.

    In plain wordsIn rats, aluminum let more labelled DSIP into the brain than in control rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseWhole-brain radioactivity after aluminum and intracarotid 125I-N-Tyr-DSIP
    Study

    ratn: not reported in source

    Comparator
    Control animals
    Outcome group
    Pharmacokinetics · Nervous system and cognition

    Measurements

    Whole-brain radioactivity increase
    45%
    aluminum 100 mg/kg versus control

    Source sentences

    Summary
    Aluminum (100 mg/kg) significantly increased the permeability of the BBB to intracarotid 125I-N-Tyr-DSIP so that levels of radioactivity in whole brain were 45% higher than in control animals.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other

    In adult rats, aluminum did not change the regional pattern of 125I-N-Tyr-DSIP radioactivity in the brain.

    In plain wordsIn rats, aluminum did not change where in the brain the labelled DSIP went.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeRegional distribution of 125I-DSIP radioactivity in the brain
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Nervous system and cognition

    Source sentences

    Summary
    The pattern of regional distribution of radioactivity in the brain was, however, unaffected, demonstrating that the affect of aluminum occurs throughout the BBB.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other

    In adult rats, the aluminum-induced 19% fall in serum inorganic phosphorus did not correlate with blood-brain barrier permeability to DSIP.

    In plain wordsIn rats, the aluminum-linked drop in blood phosphorus did not track how much labelled DSIP entered the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCorrelation of serum phosphorus decrease with BBB permeability to DSIP
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Nervous system and cognition

    Measurements

    Serum inorganic phosphorus decrease
    19%
    aluminum

    Source sentences

    Summary
    Aluminum also significantly decreased inorganic phosphorus levels in the serum by 19%, but this effect did not correlate with BBB permeability to DSIP.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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