Stimulation of spermatogenesis by gonadotropins in men with hypogonadotropic hypogonadism.

Finkel DM, Phillips JL, Snyder PJ

The New England journal of medicine1 Sept 1985Cited by 120 (Europe PMC)

PMID3927163DOI10.1056/nejm198509123131102PepBankPUB-03927163

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialEfficacy outcome
With hCG, sperm counts normalized in 6 men with postpubertal-onset hypogonadism versus 1 of 15 with prepubertal onset (P less than 0.002).
In plain wordsWith hCG, sperm counts normalized more often in men whose hypogonadism began after puberty than before puberty.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseNormal sperm count after postpubertal onset
Study
n = 21
Comparator
Men with hypogonadism beginning before puberty receiving hCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men with normal sperm count
6 men
postpubertal-onset hypogonadism, of 6
Men with normal sperm count
1 men
prepubertal-onset hypogonadism, of 15
P value
< 0.002 p value
Normal sperm count during hCG treatment, postpubertal versus prepubertal onset
Source sentences
Summary
When 21 men with hypogonadotropic hypogonadism were treated with human chorionic gonadotropin, the sperm count increased to within the normal range in the 6 in whom hypogonadism had begun after puberty, but in only 1 of the 15 in whom it had begun before puberty (P less than 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism.
Report a problemFND-0392716301
02HumanNon-randomized trialEfficacy outcome
With hCG, sperm counts normalized in only 1 of 15 men whose hypogonadotropic hypogonadism began before puberty.
In plain wordsWith hCG, sperm counts became normal in only 1 of 15 men whose hypogonadism began before puberty.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseNormal sperm count after prepubertal onset
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Measurements
Men with normal sperm count
1 men
prepubertal-onset hypogonadism, of 15
Source sentences
Summary
When 21 men with hypogonadotropic hypogonadism were treated with human chorionic gonadotropin, the sperm count increased to within the normal range in the 6 in whom hypogonadism had begun after puberty, but in only 1 of the 15 in whom it had begun before puberty (P less than 0.002).
1 context sentence(design, population, supporting numbers)
Summary · context
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism.
Report a problemFND-0392716302

Studies that did not test the peptide alone3

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

03HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
With hMG plus hCG, sperm counts normalized in 5 of 7 men without cryptorchidism versus 1 of 7 with cryptorchidism.
In plain wordsWith hMG plus hCG, sperm counts normalized more often in men without previous cryptorchidism than in men with previous cryptorchidism.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseNormal sperm count without cryptorchidism
Study
n = 14
Comparator
Men with prior cryptorchidism receiving hMG plus hCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men with normal sperm count
5 men
without cryptorchidism, of 7
Men with normal sperm count
1 men
with cryptorchidism, of 7
P value
< 0.05 p value
Normal sperm count during hMG plus hCG treatment, without versus with prior cryptorchidism
Source sentences
Summary
When the remaining 14 men with prepubertal hypogonadism were treated with human menopausal gonadotropin in addition to human chorionic gonadotropin, the sperm count increased to normal in 5 of the 7 who had not had cryptorchidism, but in only 1 of the 7 who had (P less than 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0392716303
04HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
Combined hMG and hCG normalized sperm counts in only 1 of 7 men with prepubertal hypogonadism and cryptorchidism.
In plain wordsCombined hMG and hCG normalized sperm counts in only 1 of 7 men with prepubertal hypogonadism and cryptorchidism.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseNormal sperm count with cryptorchidism
Study
n = 7
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Men with normal sperm count
1 men
with cryptorchidism, of 7
Source sentences
Summary
When the remaining 14 men with prepubertal hypogonadism were treated with human menopausal gonadotropin in addition to human chorionic gonadotropin, the sperm count increased to normal in 5 of the 7 who had not had cryptorchidism, but in only 1 of the 7 who had (P less than 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0392716304
05HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialOther
In men treated with gonadotropins, pretreatment serum and urinary FSH did not predict the need for hMG.
In plain wordsIn men treated with gonadotropins, initial blood and urinary FSH did not predict the need for hMG.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changePrediction of hMG requirement
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The need for human menopausal gonadotropin as a replacement for follicle-stimulating hormone could not be predicted by pretreatment serum and urinary levels of follicle-stimulating hormone.
1 context sentence(design, population, supporting numbers)
Summary · context
We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0392716305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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