Dermorphin inhibits basal and cold induced thyrotropin secretion in rats.

Mitsuma T, Nogimori T, Chaya M

Endocrinologia experimentalis1 Jun 1985

PMID3926450PepBankPUB-03926450

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, dermorphin significantly decreased hypothalamic ir-TRH content.
In plain wordsIn rats, dermorphin reduced hypothalamic TRH content.
Peptide
Dermorphin
Outcome
DecreaseHypothalamic ir-TRH content
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The hypothalamic immunoreactive TRH (ir-TRH) content decreased significantly after dermorphin injection, whereas its plasma concentration tended to decrease, but not significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, plasma ir-TRH concentration tended to decrease after dermorphin, but the change was not significant.
In plain wordsIn rats, plasma TRH tended to decrease after dermorphin, but the change was not significant.
Peptide
Dermorphin
Outcome
No significant changePlasma ir-TRH concentration
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The hypothalamic immunoreactive TRH (ir-TRH) content decreased significantly after dermorphin injection, whereas its plasma concentration tended to decrease, but not significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, dermorphin significantly decreased plasma TSH in a dose-related manner, with a nadir at 40 min.
In plain wordsIn rats, dermorphin reduced plasma TSH in a dose-related manner.
Peptide
Dermorphin
Outcome
DecreasePlasma TSH levels
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rats).
Source sentences
Summary
The plasma TSH levels decreased significantly in a dose-related manner with a nadir at 40 min after the injection.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, dermorphin did not significantly change plasma thyroid hormone levels.
In plain wordsIn rats, dermorphin did not significantly change plasma thyroid hormone levels.
Peptide
Dermorphin
Outcome
No significant changePlasma thyroid hormones
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The plasma thyroid hormone levels were not changed significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, dermorphin inhibited the plasma ir-TRH response to cold.
In plain wordsIn rats, dermorphin inhibited the plasma TRH response to cold.
Peptide
Dermorphin
Outcome
DecreasePlasma ir-TRH response to cold
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The plasma ir-TRH and TSH responses to cold were inhibited by dermorphin, but the plasma TSH response to TRH was not.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645005
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, dermorphin inhibited the plasma TSH response to cold.
In plain wordsIn rats, dermorphin inhibited the plasma TSH response to cold.
Peptide
Dermorphin
Outcome
DecreasePlasma TSH response to cold
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The plasma ir-TRH and TSH responses to cold were inhibited by dermorphin, but the plasma TSH response to TRH was not.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645006
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, dermorphin did not inhibit the plasma TSH response to TRH.
In plain wordsIn rats, dermorphin did not inhibit the plasma TSH response to TRH.
Peptide
Dermorphin
Outcome
No significant changePlasma TSH response to TRH
Study
ratsn: not reported in source
rats
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The plasma ir-TRH and TSH responses to cold were inhibited by dermorphin, but the plasma TSH response to TRH was not.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645007
08LabEx vivo tissueMechanism
In rat-derived in vitro samples after dermorphin injection, TRH immunoreactivity inactivation did not differ from control.
In plain wordsIn lab tests after rat dermorphin injection, TRH immunoreactivity inactivation did not differ from control.
Peptide
Dermorphin
Outcome
No significant changeTRH immunoreactivity inactivation
Study
ratsn: not reported in source
in vitro TRH immunoreactivity inactivation assay after dermorphin injection
Comparator
control
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
400 micrograms kg-1 · intravenousAs given in this study (rats).
Source sentences
Summary
The inactivation of TRH immunoreactivity by plasma of hypothalamus in vitro after dermorphin injection did not differ from that of the control.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of dermorphin on thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) secretion in rats were studied.
Summary · context
Dermorphin (400 micrograms kg-1) was injected i. v. and the rats were serially decapitated.
Report a problemFND-0392645008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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