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Study · Animal study (in vivo) · mouse · 1985

12 results

Thymosin alpha 1-induced modulation of cellular responses and functional T-cell subsets in mice with experimental autoimmune thyroiditis.

Tomazic VJ, Novotny EA, Ordonez JV

Cellular immunology1 Jul 1985Cited by 4 (Europe PMC)

PMID3873993 (opens in a new tab)DOI10.1016/0008-8749(85)90139-x (opens in a new tab)PepBankPUB-03873993
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In EAT-resistant mice, thymosin alpha‑1 given between the two antigen injections increased the level of thyroiditis.

    In plain wordsIn mice resistant to thyroid autoimmunity, thymosin alpha‑1 given early increased thyroid inflammation.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThyroiditis level in EAT-resistant mice, treatment between antigen injections
    Study

    mousen: not reported in source

    B10.D2 mice resistant to experimental autoimmune thyroiditis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.0001 to 0.1 microgram/injection · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with Ta-1 between the two antigen injections increased the level of thyroiditis in resistant mice, but had no effect in sensitive mice.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In EAT-sensitive mice, thymosin alpha‑1 given between the two antigen injections had no effect on thyroiditis.

    In plain wordsIn mice prone to thyroid autoimmunity, thymosin alpha‑1 given early had no effect on thyroid inflammation.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeThyroiditis level in EAT-sensitive mice, treatment between antigen injections
    Study

    mousen: not reported in source

    B10.Br mice sensitive to experimental autoimmune thyroiditis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.0001 to 0.1 microgram/injection · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with Ta-1 between the two antigen injections increased the level of thyroiditis in resistant mice, but had no effect in sensitive mice.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In EAT-resistant mice, thymosin alpha‑1 treatment for the first 2 weeks increased thyroiditis.

    In plain wordsIn mice resistant to thyroid autoimmunity, thymosin alpha‑1 in the first 2 weeks increased thyroid inflammation.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThyroiditis level in EAT-resistant mice, treatment in first 2 weeks
    Study

    mousen: not reported in source

    B10.D2 mice resistant to experimental autoimmune thyroiditis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.0001 to 0.1 microgram/injection · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Treatment for the first 2 weeks had similar effects in resistant mice, but also suppressed thyroiditis in the sensitive strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In EAT-sensitive mice, thymosin alpha‑1 treatment for the first 2 weeks suppressed thyroiditis.

    In plain wordsIn mice prone to thyroid autoimmunity, thymosin alpha‑1 in the first 2 weeks reduced thyroid inflammation.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThyroiditis level in EAT-sensitive mice, treatment in first 2 weeks
    Study

    mousen: not reported in source

    B10.Br mice sensitive to experimental autoimmune thyroiditis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.0001 to 0.1 microgram/injection · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Treatment for the first 2 weeks had similar effects in resistant mice, but also suppressed thyroiditis in the sensitive strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In EAT-sensitive mice, thymosin alpha‑1 given in the 3rd and 4th weeks after immunization suppressed thyroiditis.

    In plain wordsIn mice prone to thyroid autoimmunity, later thymosin alpha‑1 treatment reduced thyroid inflammation.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThyroiditis level in EAT-sensitive mice, later treatment (weeks 3 and 4)
    Study

    mousen: not reported in source

    B10.Br mice sensitive to experimental autoimmune thyroiditis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.0001 to 0.1 microgram/injection · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Later treatments, during the 3rd and 4th weeks after immunization also revealed immunomodulating properties of Ta-1, with a suppressing effect on thyroiditis in sensitive mice and an enhancing effect in the resistant strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In EAT-resistant mice, thymosin alpha‑1 given in the 3rd and 4th weeks after immunization enhanced thyroiditis.

    In plain wordsIn mice resistant to thyroid autoimmunity, later thymosin alpha‑1 treatment increased thyroid inflammation.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThyroiditis level in EAT-resistant mice, later treatment (weeks 3 and 4)
    Study

    mousen: not reported in source

    B10.D2 mice resistant to experimental autoimmune thyroiditis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.0001 to 0.1 microgram/injection · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    Later treatments, during the 3rd and 4th weeks after immunization also revealed immunomodulating properties of Ta-1, with a suppressing effect on thyroiditis in sensitive mice and an enhancing effect in the resistant strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In B10.D2 mice, thymosin alpha‑1 at 0.01 microgram greatly lowered the percentage of Lyt-2+3+ spleen cells.

    In plain wordsIn mice, a 0.01 microgram dose of thymosin alpha‑1 greatly lowered one type of T cell.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLyt-2+3+ cell percentage in D2 mice at 0.01 microgram
    Study

    mousen: not reported in source

    B10.D2 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 microgram · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    The dose of 0.01 microgram greatly lowered the percentages of Lyt-2+3+ cells in D2 mice and mildly increased the percentages in Br mice, but did not change the Lyt-1+ cell level in either strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In B10.Br mice, thymosin alpha‑1 at 0.01 microgram mildly increased the percentage of Lyt-2+3+ spleen cells.

    In plain wordsIn mice, a 0.01 microgram dose of thymosin alpha‑1 mildly raised one type of T cell.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseLyt-2+3+ cell percentage in Br mice at 0.01 microgram
    Study

    mousen: not reported in source

    B10.Br mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 microgram · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    The dose of 0.01 microgram greatly lowered the percentages of Lyt-2+3+ cells in D2 mice and mildly increased the percentages in Br mice, but did not change the Lyt-1+ cell level in either strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1 at 0.01 microgram did not change the Lyt-1+ cell level in either mouse strain.

    In plain wordsIn mice, a 0.01 microgram dose of thymosin alpha‑1 did not change Lyt-1+ T cell levels in either strain.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeLyt-1+ cell level at 0.01 microgram
    Study

    mousen: not reported in source

    B10.D2 and B10.Br mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.01 microgram · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    The dose of 0.01 microgram greatly lowered the percentages of Lyt-2+3+ cells in D2 mice and mildly increased the percentages in Br mice, but did not change the Lyt-1+ cell level in either strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In B10.D2 mice, thymosin alpha‑1 at 0.001 microgram greatly increased the percentage of Lyt-1+ spleen cells.

    In plain wordsIn mice, a 0.001 microgram dose of thymosin alpha‑1 greatly raised one type of T cell.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseLyt-1+ cell percentage in D2 mice at 0.001 microgram
    Study

    mousen: not reported in source

    B10.D2 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.001 microgram · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, the dose of 0.001 microgram greatly increased the percentage of Lyt-1+ cells in D2 mice and mildly decreased it in the Br strain, but did not alter the Lyt-2+3+ cell subset in either strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In B10.Br mice, thymosin alpha‑1 at 0.001 microgram mildly decreased the percentage of Lyt-1+ spleen cells.

    In plain wordsIn mice, a 0.001 microgram dose of thymosin alpha‑1 mildly lowered one type of T cell.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLyt-1+ cell percentage in Br mice at 0.001 microgram
    Study

    mousen: not reported in source

    B10.Br mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.001 microgram · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, the dose of 0.001 microgram greatly increased the percentage of Lyt-1+ cells in D2 mice and mildly decreased it in the Br strain, but did not alter the Lyt-2+3+ cell subset in either strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    Thymosin alpha‑1 at 0.001 microgram did not alter the Lyt-2+3+ cell subset in either mouse strain.

    In plain wordsIn mice, a 0.001 microgram dose of thymosin alpha‑1 did not change Lyt-2+3+ T cells in either strain.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeLyt-2+3+ cell subset at 0.001 microgram
    Study

    mousen: not reported in source

    B10.D2 and B10.Br mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0.001 microgram · subcutaneous · 5 or 10 daily injectionsAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, the dose of 0.001 microgram greatly increased the percentage of Lyt-1+ cells in D2 mice and mildly decreased it in the Br strain, but did not alter the Lyt-2+3+ cell subset in either strain.
    1 context sentence
    Summary · context
    The effects of Ta-1, a peptide constituent of thymosin fraction 5, were studied on murine autoimmune thyroiditis using two congenic strains of mice, B10.Br (Br) and B10.D2 (D2), which are sensitive and resistant to experimental autoimmune thyroiditis (EAT) induction, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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