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Study · Animal study (in vivo) · rat · 1985

3 results

Effects of intracerebroventricular injection of delta sleep-inducing peptide (DSIP) and an analogue on sleep and brain temperature in rats at night.

Obál F Jr, Török A, Alföldi P, Sáry G, Hajós M, Penke B

Pharmacology, biochemistry, and behavior1 Dec 1985Cited by 8 (Europe PMC)

PMID3841214 (opens in a new tab)DOI10.1016/0091-3057(85)90099-1 (opens in a new tab)PepBankPUB-03841214
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular DSIP at dark onset did not increase sleep duration compared with artificial CSF.

    In plain wordsIn rats, DSIP given into the brain at dark onset did not increase sleep compared with artificial CSF.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep duration after dark-onset injection
    Study

    ratn: not reported in source

    Comparator
    Artificial CSF
    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Relative to the control recordings obtained after artificial CSF injection, the duration of sleep did not increase after either DSIP or C-DSIP.
    1 context sentence
    Summary · context
    The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP significantly increased wakefulness 6 to 9 h after injection at dark onset.

    In plain wordsIn rats, DSIP increased time awake 6 to 9 hours after the injection, compared with artificial CSF.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseWakefulness 6 to 9 h after injection
    Study

    ratn: not reported in source

    Comparator
    Artificial CSF
    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The only significant reaction was an increase of W 6 to 9 hr after the injection of either peptide.
    1 context sentence
    Summary · context
    The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, brain temperature after DSIP followed the same course as after artificial CSF.

    In plain wordsIn rats, brain temperature after DSIP matched that after artificial CSF.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBrain temperature course
    Study

    ratn: not reported in source

    Comparator
    Artificial CSF
    Outcome group
    Body temperature · Whole body
    Studied dose
    7 nmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The course of Tbr after DSIP and C-DSIP was also identical to that recorded after the injection of artificial CSF.
    1 context sentence
    Summary · context
    The substances (7 nmol/kg) were injected at dark onset, and the sleep-wake activity and Tbr were recorded for 24 hr (dark and light periods, 12 hr each).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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