Modulation of immunoactive levels of DSIP and blood-brain permeability by lighting and diurnal rhythm.

Banks WA, Kastin AJ, Selznick JK

Journal of neuroscience research1 Jan 1985Cited by 26 (Europe PMC)

PMID3840534DOI10.1002/jnr.490140307PepBankPUB-03840534

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rats, brain and blood levels of immunoactive DSIP showed statistically significant diurnal changes.
In plain wordsIn rats, the body's own DSIP levels in brain and blood changed across the day.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
MixedDiurnal change in brain and plasma immunoactive DSIP
Study
ratn: not reported in source
Outcome group
Sleep · Nervous system and cognition
Source sentences
Summary
Both brain and blood levels of immunoactivity showed statistically significant diurnal changes
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0384053401
02AnimalEndogenous levelAnimal study (in vivo)Other
In rats, immunoactive DSIP in plasma and brain was higher in constant light and especially constant dark than in the cycled 0800 group.
In plain wordsIn rats, the body's own DSIP levels were higher in constant light or dark than in rats on a normal light cycle.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreasePlasma and brain immunoactive DSIP in constant light or dark
Study
ratn: not reported in source
Comparator
Cycled 0800 group
Outcome group
Sleep · Nervous system and cognition
Source sentences
Summary
Immunoactive levels of DSIP in both the plasma and the brain were higher
1 context sentence(design, population, supporting numbers)
Summary · context
in comparison with the cycled 0800 group.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0384053403
03AnimalEndogenous levelAnimal study (in vivo)Other
In rats kept in constant dark, blood levels of immunoactive DSIP kept varying with time of day.
In plain wordsIn rats kept in constant dark, the body's own DSIP levels in blood still rose and fell across the day.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
MixedDiurnal variation of blood immunoactive DSIP in constant dark
Study
ratn: not reported in source
Outcome group
Sleep · Nervous system and cognition
Source sentences
Summary
Diurnal variations continued to occur in the blood levels of immunoactive DSIP in the constant dark animals.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0384053405
04AnimalEndogenous levelAnimal study (in vivo)Other
In rats, plasma immunoactive DSIP correlated with brain immunoactive levels and with blood-brain barrier permeability to 125I-DSIP.
In plain wordsIn rats, the body's own DSIP levels in plasma tracked brain DSIP levels and the barrier's passage of labelled DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableCorrelation of plasma DSIP with brain DSIP and BBB permeability
Study
ratn: not reported in source
Outcome group
Sleep · Nervous system and cognition
Source sentences
Summary
Immunoactive levels of DSIP in the plasma correlated with brain immunoactive levels and with BBB permeability to 125I-DSIP.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0384053406

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other
In rats, blood-brain barrier permeability to radioiodinated DSIP varied regularly over time without statistically significant changes.
In plain wordsIn rats, the blood-brain barrier's passage of labelled DSIP varied across the day without significant change.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeDiurnal variation of BBB permeability to 125I-DSIP
Study
ratn: not reported in source
Outcome group
Pharmacokinetics · Nervous system and cognition
Source sentences
Summary
whereas the measurement of BBB permeability varied in a regular fashion over time without the changes reaching statistical significance.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0384053402
06AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other
In rats, blood-brain barrier permeability to radioiodinated DSIP increased in constant light and especially constant dark compared with the cycled 0800 group.
In plain wordsIn rats, labelled DSIP crossed the blood-brain barrier more in constant light or dark than in rats on a normal light cycle.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseBBB permeability to 125I-DSIP in constant light or dark
Study
ratn: not reported in source
Comparator
Cycled 0800 group
Outcome group
Pharmacokinetics · Nervous system and cognition
Source sentences
Summary
Immunoactive levels of DSIP in both the plasma and the brain were higher and permeability of the BBB to 125I-DSIP increased in both the constant light and especially the constant dark groups in comparison with the cycled 0800 group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0384053404
07AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Other
In rats, the increase in brain penetration of 125I-DSIP with lighting changes appeared larger after aluminum pre-treatment.
In plain wordsIn rats, aluminum pre-treatment seemed to increase how much labelled DSIP entered the brain after lighting changes.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseAluminum pre-treatment effect on 125I-DSIP brain penetration
Study
ratn: not reported in source
Outcome group
Pharmacokinetics · Nervous system and cognition
Source sentences
Summary
The increase in penetration of 125I-DSIP into the brain that occurred with changes in the lighting cycle appeared to be magnified by pre-treatment with aluminum.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-0384053407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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