Intrathecal dermorphine in postoperative analgesia.

Basso N, Marcelli M, Ginaldi A, De Marco M

Peptides1 Jan 1985Cited by 18 (Europe PMC)

PMID3831962DOI10.1016/0196-9781(85)90371-7PepBankPUB-03831962

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialSafety outcome
In postoperative patients, urinary retention did not differ significantly among dermorphine, morphine and pentazocine groups.
In plain wordsAfter surgery, urinary retention did not differ significantly among the dermorphine, morphine and pentazocine groups.
Peptide
Dermorphin
Outcome
No significant changeUrinary retention
Study
n = 150
Comparator
intrathecal morphine and routine intramuscular pentazocine
Outcome group
Adverse events · Kidney and urinary
Studied dose
20 micrograms · intrathecalAs given in this study (human).
Source sentences
Summary
Side-effects, as urinary retention, vomiting and headache, were not significantly different in the three groups of patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The effectiveness of intrathecal morphine (500 micrograms), intrathecal dermorphine (20 micrograms) and routine intramuscular pentazocine (30 mg) in the relief of postoperative pain, was compared in 150 consecutive patients after elective surgery, in a prospective randomized double blind study.
Report a problemFND-0383196204
02HumanRandomized controlled trialSafety outcome
In postoperative patients, vomiting did not differ significantly among dermorphine, morphine and pentazocine groups.
In plain wordsAfter surgery, vomiting did not differ significantly among the dermorphine, morphine and pentazocine groups.
Peptide
Dermorphin
Outcome
No significant changeVomiting
Study
n = 150
Comparator
intrathecal morphine and routine intramuscular pentazocine
Outcome group
Gastrointestinal adverse events · Gastrointestinal
Studied dose
20 micrograms · intrathecalAs given in this study (human).
Source sentences
Summary
Side-effects, as urinary retention, vomiting and headache, were not significantly different in the three groups of patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The effectiveness of intrathecal morphine (500 micrograms), intrathecal dermorphine (20 micrograms) and routine intramuscular pentazocine (30 mg) in the relief of postoperative pain, was compared in 150 consecutive patients after elective surgery, in a prospective randomized double blind study.
Report a problemFND-0383196205
03HumanRandomized controlled trialSafety outcome
In postoperative patients, headache did not differ significantly among dermorphine, morphine and pentazocine groups.
In plain wordsAfter surgery, headache did not differ significantly among the dermorphine, morphine and pentazocine groups.
Peptide
Dermorphin
Outcome
No significant changeHeadache
Study
n = 150
Comparator
intrathecal morphine and routine intramuscular pentazocine
Outcome group
Adverse events · Nervous system and cognition
Studied dose
20 micrograms · intrathecalAs given in this study (human).
Source sentences
Summary
Side-effects, as urinary retention, vomiting and headache, were not significantly different in the three groups of patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The effectiveness of intrathecal morphine (500 micrograms), intrathecal dermorphine (20 micrograms) and routine intramuscular pentazocine (30 mg) in the relief of postoperative pain, was compared in 150 consecutive patients after elective surgery, in a prospective randomized double blind study.
Report a problemFND-0383196206
04HumanRandomized controlled trialEfficacy outcome
In postoperative patients, dermorphine produced significantly longer analgesia than intrathecal morphine.
In plain wordsAfter surgery, dermorphine provided longer pain relief than intrathecal morphine.
Peptide
Dermorphin
Outcome
IncreaseAnalgesia duration versus morphine
Study
n: not reported in source
Comparator
intrathecal morphine
Outcome group
Pain · Nervous system and cognition
Studied dose
20 micrograms · intrathecalAs given in this study (human).
Measurements
Analgesia duration
43.41 hr
dermorphine
Analgesia duration
34.45 hr
morphine
Source sentences
Summary
The analgesic effect of intrathecal dermorphine was found to be profound and to last significantly longer (43.41 +/- 1.64 hr) than intrathecal morphine (34.45 +/- 2.35 hr) or the routine pentazocine therapy (10.79 +/- 2.23 hr).
1 context sentence(design, population, supporting numbers)
Summary · context
The effectiveness of intrathecal morphine (500 micrograms), intrathecal dermorphine (20 micrograms) and routine intramuscular pentazocine (30 mg) in the relief of postoperative pain, was compared in 150 consecutive patients after elective surgery, in a prospective randomized double blind study.
Report a problemFND-0383196201
05HumanRandomized controlled trialEfficacy outcome
In postoperative patients, dermorphine produced significantly longer analgesia than routine pentazocine therapy.
In plain wordsAfter surgery, dermorphine provided longer pain relief than routine pentazocine.
Peptide
Dermorphin
Outcome
IncreaseAnalgesia duration versus pentazocine
Study
n: not reported in source
Comparator
routine intramuscular pentazocine
Outcome group
Pain · Nervous system and cognition
Studied dose
20 micrograms · intrathecalAs given in this study (human).
Measurements
Analgesia duration
43.41 hr
dermorphine
Analgesia duration
10.79 hr
pentazocine
Source sentences
Summary
The analgesic effect of intrathecal dermorphine was found to be profound and to last significantly longer (43.41 +/- 1.64 hr) than intrathecal morphine (34.45 +/- 2.35 hr) or the routine pentazocine therapy (10.79 +/- 2.23 hr).
1 context sentence(design, population, supporting numbers)
Summary · context
The effectiveness of intrathecal morphine (500 micrograms), intrathecal dermorphine (20 micrograms) and routine intramuscular pentazocine (30 mg) in the relief of postoperative pain, was compared in 150 consecutive patients after elective surgery, in a prospective randomized double blind study.
Report a problemFND-0383196202
06HumanRandomized controlled trialEfficacy outcome
In postoperative patients, the dermorphine group had a significantly shorter mean hospital stay than the control group.
In plain wordsAfter surgery, the dermorphine group had a shorter hospital stay than the control group.
Peptide
Dermorphin
Outcome
DecreasePostoperative hospital stay
Study
n: not reported in source
Comparator
control group
Outcome group
Intensive care and hospital outcomes · Whole body
Studied dose
20 micrograms · intrathecalAs given in this study (human).
Measurements
Hospital stay
5.6
dermorphine group
Hospital stay
8.7
control group
Source sentences
Summary
The mean postoperative hospital stay in the intrathecal dermorphine (5.6 +/- 4) and morphine groups (6.3 +/- 45) was significantly shorter than in the control group (8.7 +/- 42).
1 context sentence(design, population, supporting numbers)
Summary · context
The effectiveness of intrathecal morphine (500 micrograms), intrathecal dermorphine (20 micrograms) and routine intramuscular pentazocine (30 mg) in the relief of postoperative pain, was compared in 150 consecutive patients after elective surgery, in a prospective randomized double blind study.
Report a problemFND-0383196203

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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