Skip to content

Study · Animal study (in vivo) · rat · 1985

4 results

Cross-tolerance between dermorphin and morphine to analgesia and catalepsy in rats.

Broccardo M, Improta G

Peptides1 Jan 1985Cited by 5 (Europe PMC)

PMID3831961 (opens in a new tab)DOI10.1016/0196-9781(85)90369-9 (opens in a new tab)PepBankPUB-03831961
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, continuous dermorphin infusion induced tolerance to its analgesic effects.

    In plain wordsIn rats, continuous dermorphin infusion reduced the analgesic response to dermorphin.

    Peptide
    Dermorphin
    Outcome
    DecreaseTolerance to analgesia
    Study

    ratsn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · ICVAs given in this study (rats).

    Source sentences

    Summary
    Both dermorphin and morphine induced tolerance to the analgesic and cataleptic effects.
    2 context sentences
    Summary · context
    Tolerance to the analgesic effect was assessed by evaluating the shift of the ED50 of dermorphin or morphine in dermorphin-infused or in morphine-infused animal respectively, after single doses of these opioids.
    Summary · context
    Rats were made tolerant to dermorphin or to morphine by continuous ICV infusion of these drugs.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, continuous dermorphin infusion induced tolerance to its cataleptic effects.

    In plain wordsIn rats, continuous dermorphin infusion reduced the cataleptic response to dermorphin.

    Peptide
    Dermorphin
    Outcome
    DecreaseTolerance to catalepsy
    Study

    ratsn: not reported in source

    rats
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · ICVAs given in this study (rats).

    Source sentences

    Summary
    Both dermorphin and morphine induced tolerance to the analgesic and cataleptic effects.
    2 context sentences
    Summary · context
    Tolerance to catalepsy was revealed with the significant reduction of this effect after single ICV dose of morphine in morphine-infused and dermorphin in dermorphin-infused rats.
    Summary · context
    Rats were made tolerant to dermorphin or to morphine by continuous ICV infusion of these drugs.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In morphine-tolerant rats, acute dermorphin had significantly decreased analgesic potency, indicating cross-tolerance.

    In plain wordsIn morphine-tolerant rats, acute dermorphin had lower analgesic potency.

    Peptide
    Dermorphin
    Outcome
    DecreaseAnalgesic potency in morphine-tolerant rats
    Study

    ratsn: not reported in source

    rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · ICVAs given in this study (rats).

    Source sentences

    Summary
    Acute injections of dermorphin (ICV) in MOR-tolerant rats, while significantly decreasing its analgesic potency, indicating the development of cross-tolerance,
    1 context sentence
    Summary · context
    Rats were made tolerant to dermorphin or to morphine by continuous ICV infusion of these drugs.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In morphine-tolerant rats, the cataleptic response to dermorphin did not change, indicating no cross-tolerance for this effect.

    In plain wordsIn morphine-tolerant rats, the cataleptic response to dermorphin did not change.

    Peptide
    Dermorphin
    Outcome
    No significant changeCataleptic response in morphine-tolerant rats
    Study

    ratsn: not reported in source

    rats
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · ICVAs given in this study (rats).

    Source sentences

    Summary
    did not modify the cataleptic response to the peptide, showing that no cross-tolerance was present to this effect.
    1 context sentence
    Summary · context
    Rats were made tolerant to dermorphin or to morphine by continuous ICV infusion of these drugs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.