Electroencephalographic and autonomic effects of centrally administered dermorphin in rabbits.

Tartara A, Maurelli M, Marchioni E

Peptides1 Jan 1985Cited by 3 (Europe PMC)

PMID3831958DOI10.1016/0196-9781(85)90365-1PepBankPUB-03831958

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In conscious rabbits, dermorphin increased the cortical total power density spectrum.
In plain wordsIn rabbits, dermorphin increased the total power density spectrum of the cortex.
Peptide
Dermorphin
Outcome
IncreaseCortical total power density spectrum
Study
rabbitsn: not reported in source
conscious rabbits
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · third ventricleAs given in this study (rabbits).
Source sentences
Summary
Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus.
Report a problemFND-0383195801
02AnimalAnimal study (in vivo)Efficacy outcome
In conscious rabbits, dermorphin decreased hippocampal total power.
In plain wordsIn rabbits, dermorphin decreased the total power of the hippocampus.
Peptide
Dermorphin
Outcome
DecreaseHippocampal total power
Study
rabbitsn: not reported in source
conscious rabbits
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · third ventricleAs given in this study (rabbits).
Source sentences
Summary
Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus.
Report a problemFND-0383195802
03AnimalAnimal study (in vivo)Safety outcome
In rabbits, dermorphin caused respiratory depression.
In plain wordsIn rabbits, dermorphin caused respiratory depression.
Peptide
Dermorphin
Outcome
IncreaseRespiratory depression
Study
rabbitsn: not reported in source
conscious rabbits
Outcome group
Adverse events · Respiratory
Studied dose
Dose not stated · third ventricleAs given in this study (rabbits).
Source sentences
Summary
Simultaneously the peptide causes respiratory depression, bradycardia and hypothermia.
1 context sentence(design, population, supporting numbers)
Summary · context
Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus.
Report a problemFND-0383195803
04AnimalAnimal study (in vivo)Safety outcome
In rabbits, dermorphin caused bradycardia.
In plain wordsIn rabbits, dermorphin caused a slow heart rate.
Peptide
Dermorphin
Outcome
IncreaseBradycardia
Study
rabbitsn: not reported in source
conscious rabbits
Outcome group
Adverse events · Cardiovascular
Studied dose
Dose not stated · third ventricleAs given in this study (rabbits).
Source sentences
Summary
Simultaneously the peptide causes respiratory depression, bradycardia and hypothermia.
1 context sentence(design, population, supporting numbers)
Summary · context
Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus.
Report a problemFND-0383195804
05AnimalAnimal study (in vivo)Safety outcome
In rabbits, dermorphin caused hypothermia.
In plain wordsIn rabbits, dermorphin caused low body temperature.
Peptide
Dermorphin
Outcome
IncreaseHypothermia
Study
rabbitsn: not reported in source
conscious rabbits
Outcome group
Adverse events · Whole body
Studied dose
Dose not stated · third ventricleAs given in this study (rabbits).
Source sentences
Summary
Simultaneously the peptide causes respiratory depression, bradycardia and hypothermia.
1 context sentence(design, population, supporting numbers)
Summary · context
Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus.
Report a problemFND-0383195805
06AnimalAnimal study (in vivo)Mechanism
In rabbits, the dermorphin electrocortical pattern resembled that reported for other opiates and mu agonists.
In plain wordsIn rabbits, dermorphin produced a brain electrical pattern similar to other opiates.
Peptide
Dermorphin
Outcome
Not applicableElectrocortical pattern
Study
rabbitsn: not reported in source
conscious rabbits
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · third ventricleAs given in this study (rabbits).
Source sentences
Summary
The electrocortical pattern is similar to that found with other opiates and reported as specific of mu agonists.
1 context sentence(design, population, supporting numbers)
Summary · context
Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus.
Report a problemFND-0383195806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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