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Study · Not a test of the peptide alone · 1986

4 results

[Peptidergic modulation of sleep: a comparative study of analogs of the peptide DSIP].

Koval'zon VM, Obál F Jr, Kalikhevich VN

Zhurnal evoliutsionnoi biokhimii i fiziologii1 Sept 1986

PMID3788358 (opens in a new tab)PepBankPUB-03788358
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits, the DSIP analogues (D-Trp1) DSIP and (D-Tyr1) DSIP increased total sleep time, mainly slow wave sleep, during the first 3-5 hours versus control injections.

    In plain wordsIn rabbits, two DSIP-like compounds increased total sleep time in the first 3-5 hours compared with control injections.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTotal sleep time
    Study

    rabbitn: not reported in source

    Comparator
    Control injections to the same animals
    Outcome group
    Sleep · Sleep

    Measurements

    Duration of increased total sleep time
    3 to 5 h
    rabbits

    Source sentences

    Summary
    Significant increase of total sleep time (mainly due to slow wave sleep) after administration of the peptides (D-Trp1) DSIP and (D-Tyr1) DSIP as compared with the control injections to the same animals was found during the first 3-5 hours in rabbits and 12 hours in rats.
    1 context sentence
    Summary · context
    Effects of intracerebroventricular administration of 3 DSIP analogues with higher stability against proteolysis, on subsequent sleep were studied in rabbits and rats previously implanted with electrodes and cannulas.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rats, the DSIP analogues (D-Trp1) DSIP and (D-Tyr1) DSIP increased total sleep time, mainly slow wave sleep, over 12 hours versus control injections.

    In plain wordsIn rats, two DSIP-like compounds increased total sleep time over 12 hours compared with control injections.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTotal sleep time
    Study

    ratn: not reported in source

    Comparator
    Control injections to the same animals
    Outcome group
    Sleep · Sleep

    Measurements

    Duration of increased total sleep time
    12 h
    rats

    Source sentences

    Summary
    Significant increase of total sleep time (mainly due to slow wave sleep) after administration of the peptides (D-Trp1) DSIP and (D-Tyr1) DSIP as compared with the control injections to the same animals was found during the first 3-5 hours in rabbits and 12 hours in rats.
    1 context sentence
    Summary · context
    Effects of intracerebroventricular administration of 3 DSIP analogues with higher stability against proteolysis, on subsequent sleep were studied in rabbits and rats previously implanted with electrodes and cannulas.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits, the shortened DSIP analogue (D-Trp1) DSIP1-6 had no effect on sleep.

    In plain wordsIn rabbits, a shortened DSIP-like compound had no effect on sleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep with shortened analogue (D-Trp1) DSIP1-6
    Study

    rabbitn: not reported in source

    Comparator
    Control injections to the same animals
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Shortened analogue (D-Trp1) DSIP1-6 had no effect on rabbit sleep
    1 context sentence
    Summary · context
    Effects of intracerebroventricular administration of 3 DSIP analogues with higher stability against proteolysis, on subsequent sleep were studied in rabbits and rats previously implanted with electrodes and cannulas.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  4. 04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rats, the shortened DSIP analogue (D-Trp1) DSIP1-6 significantly reduced slow wave sleep during the first 3 hours.

    In plain wordsIn rats, a shortened DSIP-like compound reduced slow wave sleep during the first 3 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSlow wave sleep with shortened analogue (D-Trp1) DSIP1-6
    Study

    ratn: not reported in source

    Comparator
    Control injections to the same animals
    Outcome group
    Sleep · Sleep

    Measurements

    Duration of reduced slow wave sleep
    3 h
    rats

    Source sentences

    Summary
    significantly reduced slow wave sleep in rats during the first 3 hours.
    1 context sentence
    Summary · context
    Effects of intracerebroventricular administration of 3 DSIP analogues with higher stability against proteolysis, on subsequent sleep were studied in rabbits and rats previously implanted with electrodes and cannulas.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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